ArticleBMC biology2008
Characterization of the proneural gene regulatory network during mouse telencephalon development.
Article in BMC biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 104 citations in OpenAlex.
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- Understanding the impact of ZBTB18 missense variation on transcription factor function in neurodevelopment and disease.Journal of neurochemistry · 2022Review
- Gadd45 in Neuronal Development, Function, and Injury.Advances in experimental medicine and biology · 2022Review
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- Integral bHLH factor regulation of cell cycle exit and RGC differentiation.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Human Accelerated Regions and Other Human-Specific Sequence Variations in the Context of Evolution and Their Relevance for Brain Development.Genome biology and evolution · 2018Review
- The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain.Neural development · 2016Article
- Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming.Stem cell reports · 2016Article
- MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis.Cell reports · 2016Article
- Complex translocation disrupting TCF4 and altering TCF4 isoform expression segregates as mild autosomal dominant intellectual disability.Orphanet journal of rare diseases · 2016Article
- Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes.Cell stem cell · 2015Article
- Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex.Nature neuroscience · 2015Article
- Transcriptional regulatory events initiated by Ascl1 and Neurog2 during neuronal differentiation of P19 embryonic carcinoma cells.Journal of molecular neuroscience : MN · 2015Article
- Quantitative and logic modelling of molecular and gene networks.Nature reviews. Genetics · 2015Review
- Rapid neurogenesis through transcriptional activation in human stem cells.Molecular systems biology · 2014Article
- Pax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers.Developmental biology · 2014Article
- Globularity and language-readiness: generating new predictions by expanding the set of genes of interest.Frontiers in psychology · 2014Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundThe proneural proteins Mash1 and Ngn2 are key cell autonomous regulators of neurogenesis in the mammalian central nervous system, yet little is known about the molecular pathways regulated by these transcription factors.
resultsHere we identify the downstream effectors of proneural genes in the telencephalon using a genomic approach to analyze the transcriptome of mice that are either lacking or overexpressing proneural genes. Novel targets of Ngn2 and/or Mash1 were identified, such as members of the Notch and Wnt pathways, and proteins involved in adhesion and signal transduction. Next, we searched the non-coding sequence surrounding the predicted proneural downstream effector genes for evolutionarily conserved transcription factor binding sites associated with newly defined consensus binding sites for Ngn2 and Mash1. This allowed us to identify potential novel co-factors and co-regulators for proneural proteins, including Creb, Tcf/Lef, Pou-domain containing transcription factors, Sox9, and Mef2a. Finally, a gene regulatory network was delineated using a novel Bayesian-based algorithm that can incorporate information from diverse datasets.
conclusionTogether, these data shed light on the molecular pathways regulated by proneural genes and demonstrate that the integration of experimentation with bioinformatics can guide both hypothesis testing and hypothesis generation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.