ArticleCancer science2008
Adiponectin and colorectal adenomas: Self Defense Forces Health Study.
Article in Cancer science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- The role of Adiponectin and Leptin in Colorectal Cancer and Adenoma: a systematic review and meta-analysis.BMC cancer · 2025Pooled it
- Systemic adiponectin levels in colorectal cancer and adenoma: a systematic review and meta-analysis.International journal of obesity (2005) · 2023Pooled it
- Circulating levels of C-reactive protein, interleukin-6 and tumor necrosis factor-α and risk of colorectal adenomas: a meta-analysis.Oncotarget · 2016Pooled it
- Circulating adiponectin levels in various malignancies: an updated meta-analysis of 107 studies.Oncotarget · 2016Pooled it
- Metabolomic signatures of inflammation and metabolic dysregulation in relation to colorectal cancer risk.Journal of the National Cancer Institute · 2024Article
- Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans.Frontiers in endocrinology · 2018Article
- Adiponectin and colorectal cancer.Surgery today · 2017Review
- Specific metabolic biomarkers as risk and prognostic factors in colorectal cancer.World journal of gastroenterology · 2014Review
- Obesity and colorectal cancer: role of adipokines in tumor initiation and progression.World journal of gastroenterology · 2014Review
- Adipokines do not mediate the association of obesity and colorectal adenoma.Journal of cancer epidemiology · 2014Article
- Adipokines and obesity are associated with colorectal polyps in adult males: a cross-sectional study.PloS one · 2014Article
- Association of plasma total and high-molecular-weight adiponectin with risk of colorectal cancer: an observational study in Chinese male.Medical oncology (Northwood, London, England) · 2012Article
- The adiponectin gene, ADIPOQ, and genetic susceptibility to colon cancer.Oncology letters · 2012Article
- Adiposity factors are not related to the presence of colorectal adenomas.Clinical and experimental gastroenterology · 2011Article
- Circulating vitamin D and colorectal adenomas in Japanese men.Cancer science · 2010Article
- Adiponectin represses colon cancer cell proliferation via AdipoR1- and -R2-mediated AMPK activation.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Serum adiponectin, leptin, C-peptide, homocysteine, and colorectal adenoma recurrence in the Polyp Prevention Trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2010Article
- Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer.World journal of gastroenterology · 2010Article
- C-reactive protein and colorectal adenomas: Self Defense Forces Health Study.Cancer science · 2009Article
- Serum leptin, adiponectin, and resistin concentration in colorectal adenoma and carcinoma (CC) patients.International journal of colorectal disease · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adiponectin is an adipocyte-derived protein with an insulin-sensitizing action. Circulating levels of adiponectin are inversely correlated with obesity, especially abdominal obesity. Some studies have suggested that low levels of circulating adiponectin might be related to increased risk of colorectal cancer and adenomas. The present study examined the relationship between total and high-molecular-weight (HMW) adiponectin to colorectal adenomas in the Self Defense Forces (SDF) Health Study. The study subjects comprised 656 cases of colorectal adenomas and 648 controls with normal colonoscopy among men receiving a preretirement health examination at two Self Defense Forces hospitals. Total and HMW adiponectin were slightly lower in adenoma cases than in controls; geometric means of total adiponectin were 5.42 microg/mL in cases and 5.63 microg/mL in controls (P = 0.13), and the corresponding values of HMW adiponectin were 2.47 microg/mL and 2.57 microg/mL, respectively (P = 0.29). Regardless of adjustment for body mass index and other lifestyle factors, total adiponectin was unrelated to the risk of colorectal adenomas. Total adiponectin levels were inversely related to the risk of large adenomas (>or= 5 mm), but not of small adenomas, with a nearly statistically significant decreasing trend (P = 0.06). However, the inverse association was largely ascribed to body mass index and other lifestyle factors. HMW adiponectin showed no clear association with either overall or size-specific risk of colorectal adenomas. The study provided suggestive evidence for a protective association between adiponectin and large adenomas, but did not indicate a protective association independent of adiposity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.