ArticleExperimental biology and medicine (Maywood, N.J.)2008
Zinc supplementation inhibits hepatic apoptosis in mice subjected to a long-term ethanol exposure.
Article in Experimental biology and medicine (Maywood, N.J.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Randomized trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis.Journal of hepatology · 2024Trial
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- Toxicity and Hepatoprotective Effects of ZnO Nanoparticles on Normal and High-Fat Diet-Fed Rat Livers: Mechanism of Action.Biological trace element research · 2025Article
- Article
- Effect of Dietary Zinc Methionine Supplementation on Growth Performance, Immune Function and Intestinal Health of Cherry Valley Ducks Challenged With Avian PathogenicFrontiers in microbiology · 2022Article
- Ameliorative effect of ZnO-NPs against bioaggregation and systemic toxicity of lead oxide in some organs of albino rats.Environmental science and pollution research international · 2021Article
- Zinc deficiency as a mediator of toxic effects of alcohol abuse.European journal of nutrition · 2018Review
- Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats.Iranian journal of medical sciences · 2018Article
- Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice.Scientific reports · 2017Article
- Role of Zinc in the Development/Progression of Alcoholic Liver Disease.Current treatment options in gastroenterology · 2017Review
- Systematic review of zinc biochemical indicators and risk of coronary heart disease.ARYA atherosclerosis · 2015Review
- Zinc deficiency mediates alcohol-induced apoptotic cell death in the liver of rats through activating ER and mitochondrial cell death pathways.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases.World journal of gastroenterology · 2014Review
- Protective effect of grape seed and skin extract against high-fat diet-induced liver steatosis and zinc depletion in rat.Digestive diseases and sciences · 2014Article
- Alcoholism causes alveolar macrophage zinc deficiency and immune dysfunction.American journal of respiratory and critical care medicine · 2013Article
- Feeding low or pharmacological concentrations of zinc oxide changes the hepatic proteome profiles in weaned piglets.PloS one · 2013Article
- The protective effect of quercetin on long-term alcohol consumption-induced oxidative stress.Molecular biology reports · 2012Article
- Oxidative stress and benefits of antioxidant agents in acute and chronic hepatitis.Hepatitis monthly · 2012Article
- Zinc and liver disease.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2012Review
- Zinc deprivation mediates alcohol-induced hepatocyte IL-8 analog expression in rodents via an epigenetic mechanism.The American journal of pathology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Hepatocyte apoptosis has been documented in both clinical and experimental alcoholic liver disease. This study was undertaken to examine the effect of dietary zinc supplementation on hepatic apoptosis in mice subjected to a long-term ethanol exposure. Male adult 129S6 mice fed an ethanol-containing liquid diet for 6 months developed hepatitis, as indicated by neutrophil infiltration and elevation of hepatic keratinocyte chemoattractant (KC) and monocyte chemoattractant protein-1 (MCP-1) levels. Apoptotic cell death was detected in ethanol-exposed mice by a terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and was confirmed by the increased activities of caspase-3 and -8. Zinc supplementation attenuated alcoholic hepatitis and reduced the number of TUNEL-positive cells in association with inhibition of caspase activities. Ethanol exposure caused oxidative stress, as indicated by reactive oxygen species accumulation, mitochondrial glutathione depletion, and decreased metallothionein levels in the liver, which were suppressed by zinc supplementation. The mRNA levels of tumor necrosis factor (TNF)-alpha, TNF-R1, FasL, Fas, Fas-associated factor-1, and caspase-3 in the liver were upregulated by ethanol exposure, which were attenuated by zinc supplementation. Zinc supplementation also prevented ethanol-elevated serum and hepatic TNF-alpha levels and TNF-R1 and Fas proteins in the liver. In conclusion, zinc supplementation prevented hepatocyte apoptosis in mice subjected to long-term ethanol exposure, and the action of zinc is likely through suppression of oxidative stress and death receptor-mediated pathways.
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Registered trials
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