ArticleEukaryotic cell2008
Saccharomyces cerevisiae phospholipase C regulates transcription of Msn2p-dependent stress-responsive genes.
Article in Eukaryotic cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Genome-wide identification of the SAM-dependent methyltransferase members and functional analysis of GmSAMMt30 in soybean (Glycine max) under salt-alkali stress.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Phospholipase C: Diverse functions in plant biotic stress resistance and fungal pathogenicity.Molecular plant pathology · 2023Review
- Phosphorylation of the Gα protein Gpa2 promotes protein kinase A signaling in yeast.The Journal of biological chemistry · 2019Article
- pH homeostasis in yeast; the phosphate perspective.Current genetics · 2018Review
- Yeast phospholipase C is required for stability of casein kinase I Yck2p and expression of hexose transporters.FEMS microbiology letters · 2017Article
- Histone hypoacetylation-activated genes are repressed by acetyl-CoA- and chromatin-mediated mechanism.Biochimica et biophysica acta · 2014Article
- Yeast phospholipase C is required for normal acetyl-CoA homeostasis and global histone acetylation.The Journal of biological chemistry · 2013Article
- Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiae.The Journal of biological chemistry · 2013Article
- Acetyl-CoA carboxylase regulates global histone acetylation.The Journal of biological chemistry · 2012Article
- Facilitated assembly of the preinitiation complex by separated tail and head/middle modules of the mediator.Journal of molecular biology · 2012Article
- Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling.Molecular genetics and genomics : MGG · 2011Article
- A network-based approach on elucidating the multi-faceted nature of chronological aging in S. cerevisiae.PloS one · 2011Article
- Role of phospholipases in fungal fitness, pathogenicity, and drug development - lessons from cryptococcus neoformans.Frontiers in microbiology · 2010Article
- Role of Plc1p in regulation of Mcm1p-dependent genes.FEMS microbiology letters · 2009Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Phosphatidylinositol phosphates are involved in signal transduction, cytoskeletal organization, and membrane trafficking. Inositol polyphosphates, produced from phosphatidylinositol phosphates by the phospholipase C-dependent pathway, regulate chromatin remodeling. We used genome-wide expression analysis to further investigate the roles of Plc1p (phosphoinositide-specific phospholipase C in Saccharomyces cerevisiae) and inositol polyphosphates in transcriptional regulation. Plc1p contributes to the regulation of approximately 2% of yeast genes in cells grown in rich medium. Most of these genes are induced by nutrient limitation and other environmental stresses and are derepressed in plc1 Delta cells. Surprisingly, genes regulated by Plc1p do not correlate with gene sets regulated by Swi/Snf or RSC chromatin remodeling complexes but show correlation with genes controlled by Msn2p. Our results suggest that the increased expression of stress-responsive genes in plc1 Delta cells is mediated by decreased cyclic AMP synthesis and protein kinase A (PKA)-mediated phosphorylation of Msn2p and increased binding of Msn2p to stress-responsive promoters. Accordingly, plc1 Delta cells display other phenotypes characteristic of cells with decreased PKA activity. Our results are consistent with a model in which Plc1p acts together with the membrane receptor Gpr1p and associated G(alpha) protein Gpa2p in a pathway separate from Ras1p/Ras2p and converging on PKA.
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