ArticleJournal of bacteriology2008
Repair and antirepair DNA helicases in Helicobacter pylori.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Interaction of branch migration translocases with the Holliday junction-resolving enzyme and their implications in Holliday junction resolution.The Journal of biological chemistry · 2014Article
- DprB facilitates inter- and intragenomic recombination in Helicobacter pylori.Journal of bacteriology · 2012Article
- Xer recombinase and genome integrity in Helicobacter pylori, a pathogen without topoisomerase IV.PloS one · 2012Article
- Biochemical and cellular characterization of Helicobacter pylori RecA, a protein with high-level constitutive expression.Journal of bacteriology · 2011Article
- Change is good: variations in common biological mechanisms in the epsilonproteobacterial genera Campylobacter and Helicobacter.Microbiology and molecular biology reviews : MMBR · 2011Review
- Characterization of Helicobacter pylori factors that control transformation frequency and integration length during inter-strain DNA recombination.Molecular microbiology · 2011Article
- Recombination and DNA repair in Helicobacter pylori.Annual review of microbiology · 2011Review
- Repeat-associated plasticity in the Helicobacter pylori RD gene family.Journal of bacteriology · 2009Article
- The extent of migration of the Holliday junction is a crucial factor for gene conversion in Rhizobium etli.Journal of bacteriology · 2009Article
- Natural transformation of helicobacter pylori involves the integration of short DNA fragments interrupted by gaps of variable size.PLoS pathogens · 2009Article
- The cell pole: the site of cross talk between the DNA uptake and genetic recombination machinery.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthologs of RecG and RuvABC are highly conserved among prokaryotes; in Escherichia coli, they participate in independent pathways that branch migrate Holliday junctions during recombinational DNA repair. RecG also has been shown to directly convert stalled replication forks into Holliday junctions. The bacterium Helicobacter pylori, with remarkably high levels of recombination, possesses RecG and RuvABC homologs, but in contrast to E. coli, H. pylori RecG limits recombinational repair. We now show that the RuvABC pathway plays the prominent, if not exclusive, repair role. By introducing an E. coli resolvase (RusA) into H. pylori, the repair and recombination phenotypes of the ruvB mutant but not the recG mutant were improved. Our results indicate that RecG and RuvB compete for Holliday junction structures in recombinational repair, but since a classic RecG resolvase is absent from H. pylori, deployment of the RecG pathway is lethal. We propose that evolutionary loss of the H. pylori RecG resolvase provides an "antirepair" pathway allowing for selection of varied strains. Such competition between repair and antirepair provides a novel mechanism to maximize fitness at a bacterial population level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.