ArticleAnnals of the rheumatic diseases2009
Overnight variations in cortisol, interleukin 6, tumour necrosis factor alpha and other cytokines in people with rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 128 citations in OpenAlex.
- Morning stiffness response with delayed-release prednisone after ineffective course of immediate-release prednisone.Scandinavian journal of rheumatology · 2015Trial
- Acute exposure to 50-Hz magnetic fields increases interleukin-6 in young healthy men.Journal of clinical immunology · 2011Trial
- Targeting pathophysiological rhythms: prednisone chronotherapy shows sustained efficacy in rheumatoid arthritis.Annals of the rheumatic diseases · 2010Trial
- High drug-loaded supramolecular microgels enabled by controlled in-droplet self-assembly for adaptive treatment of inflammatory arthritis.Bioactive materials · 2026Article
- Interleukin-6 blockade modulates monocyte recruitment to protect against diastolic dysfunction associated with inflammatory arthritis.Arthritis research & therapy · 2026Article
- Biological Clock Perspective in Rheumatoid Arthritis.Inflammation · 2025Review
- Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis.Open biology · 2024Article
- Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases.Cells · 2023Review
- Butterflies in the gut: the interplay between intestinal microbiota and stress.Journal of biomedical science · 2023Review
- Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad?Endocrine reviews · 2023Review
- The Associations of Chronotype and Shift Work With Rheumatoid Arthritis.Journal of biological rhythms · 2023Article
- Circadian Regulation of Macrophages and Osteoclasts in Rheumatoid Arthritis.International journal of molecular sciences · 2023Review
- Perspectives of colon-specific drug delivery in the management of morning symptoms of rheumatoid arthritis.Inflammopharmacology · 2023Review
- Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Adaptive immunity, chronic inflammation and the clock.Seminars in immunopathology · 2022Review
- Morning Chronotype Decreases the Risk of Chemotherapy-Induced Peripheral Neuropathy in Women With Breast Cancer.Journal of Korean medical science · 2022Article
- Light-induced synchronization of the SCN coupled oscillators and implications for entraining the HPA axis.Frontiers in endocrinology · 2022Article
- Identifying hub circadian rhythm biomarkers and immune cell infiltration in rheumatoid arthritis.Frontiers in immunology · 2022Article
- Chrono-moxibustion adjusts circadian rhythm of CLOCK and BMAL1 in adjuvant-induced arthritic rats.American journal of translational research · 2022Article
- Circadian rhythms in septic shock patients.Annals of intensive care · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo investigate overnight variations in absolute values and patterns of cytokines including interleukin 6 (IL6) and tumour necrosis factor alpha (TNFalpha) in rheumatoid arthritis (RA), and to relate any changes to those occurring in blood cortisol.
methodsA total of 16 people (8 female) with active RA and who had received no recent glucocorticoids were admitted overnight. Blood samples were obtained at 13 time points between 21.00 and 10.00.
resultsThe geometric mean IL6 concentration rose significantly from 35 pg/ml at 22:00 to 64 pg/ml at 07:15 (repeated measures analysis of variance (ANOVA), p<0.001). The geometric mean cortisol concentration rose significantly overnight from 57 ng/ml at 01:00 to 229 ng/ml at 07:15 (repeated measures ANOVA, p<0.001). Neither TNFalpha nor the other cytokines measured changed significantly. Using cubic regression modelling IL6 began to rise before cortisol (range 0.01 to 4.83 h) in eight participants and after cortisol (range 1.11 to 5.14 h) in three participants. In a random coefficient model including data from all participants, the estimated mean IL6 value began to rise 3.05 h before the estimated mean cortisol value, with the IL6 peak occurring 0.70 h before the cortisol peak.
conclusionThe mean IL6 and cortisol concentrations showed a significant overnight variation. Neither TNFalpha nor the other cytokines measured changed significantly. In a random coefficient model IL6 began to rise approximately 3 h, and reached a peak about 40 min, before cortisol. These studies confirm that there are abnormalities in plasma cortisol and IL6 concentrations and dynamics. The data also link the overnight rise in IL6 to the circadian variation in symptoms.
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Registered trials
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