Trial reportQJM : monthly journal of the Association of Physicians2008
Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning.
Trial report in QJM : monthly journal of the Association of Physicians, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Oximes for acute organophosphate pesticide poisoning.The Cochrane database of systematic reviews · 2011Pooled it
- Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides.Toxicological sciences : an official journal of the Society of Toxicology · 2013Trial
- Comparative analysis of ingestion assessment methods in paraquat-poisoned patients.European journal of medical research · 2025Article
- Assessing Diazinon Exposure: A GC-MS/MS Validation Study of BChE Measurement by Point-of-Care Testing and Enzyme Multiplied Immunoassay Technique.Molecules (Basel, Switzerland) · 2025Article
- Relationship between butyrylcholinesterase activity and hepatic transaminases: a cross-sectional study in agricultural workers from Peru.Journal of occupational medicine and toxicology (London, England) · 2025Article
- Organophosphate Poisoning: Review of Prognosis and Management.Advanced biomedical research · 2024Review
- Toxic-Induced Nonthyroidal Illness Syndrome Induced by Acute Low-Dose Pesticides Exposure-Preliminary In Vivo Study.Toxics · 2022Article
- Microglia Remodelling and Neuroinflammation Parallel Neuronal Hyperactivation Following Acute Organophosphate Poisoning.International journal of molecular sciences · 2022Article
- Inhibition of Serum Esterases in Juvenile Rats Repeatedly Exposed to Low Levels of Chlorpyrifos.International journal of scientific research in environmental science and toxicology · 2022Article
- Clinical Analysis of Acute Organophosphorus Pesticide Poisoning and Successful Cardiopulmonary Resuscitation: A Case Series.Frontiers in public health · 2022Article
- Case Fatality as an Indicator for the Human Toxicity of Pesticides-A Systematic Scoping Review on the Availability and Variability of Severity Indicators of Pesticide Poisoning.International journal of environmental research and public health · 2021Article
- Phytopharmacological Evaluation of Different Solvent Extract/Fractions FromFrontiers in pharmacology · 2021Article
- Successful management of zinc phosphide poisoning-a Hungarian case.International journal of emergency medicine · 2020Article
- Organophosphorus pesticide determination in biological specimens: bioanalytical and toxicological aspects.International journal of legal medicine · 2019Review
- Usefulness of serum lactate as a predictor of successful discontinuation of continuous atropine infusion in patients with severe acute organophosphate poisoning.Clinical and experimental emergency medicine · 2018Article
- Chimeric mice with humanized liver as a model for testing organophosphate and carbamate pesticide exposure.Pest management science · 2018Article
- Enzymatic detoxification of organophosphorus pesticides and related toxicants.Journal of pesticide science · 2018Article
- Pseudocholinesterase as a predictor of mortality and morbidity in organophosphorus poisoning.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2016Article
- Profile of adult acute cholinesterase inhibitors substances poisoning - a 30 years analysis.Open medicine (Warsaw, Poland) · 2015Article
- Clinical features of organophosphate poisoning: A review of different classification systems and approaches.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe usefulness of a low butyrylcholinesterase (BuChE) activity on admission for predicting severity in acute organophosphorus (OP) insecticide poisoning has long been debated. Previous studies have been confounded by the inclusion of multiple insecticides with differing inhibitory kinetics.
aimWe aimed to assess the usefulness of admission BuChE activity, together with plasma OP concentration, for predicting death with two specific organophosphorus insecticides.
designA prospective cohort of self-poisoned patients.
methodsWe prospectively studied 91 and 208 patients with proven dimethoate or chlorpyrifos self-poisoning treated using a standard protocol. Plasma butyrylcholinesterase activity and OP concentration were measured on admission and clinical outcomes recorded.
resultsThe usefulness of a plasma BuChE activity <600 mU/ml on admission varied markedly--while highly sensitive in chlorpyrifos poisoning (sensitivity 11/11 deaths; 100%, 95% CI 71.5-100), its specificity was only 17.7% (12.6-23.7). In contrast, while poorly sensitive for deaths in dimethoate poisoning [12/25 patients; 48%, (27.9-68.7)] it was reasonably specific [86.4% (75.7-93.6)]. A high OP concentration on admission was associated with worse outcome; however, a clear threshold concentration was only present for dimethoate poisoning.
conclusionPlasma BuChE activity on admission can provide useful information; however, it must be interpreted carefully. It can only be used to predict death when the insecticide ingested is known and its sensitivity and specificity for that insecticide has been studied. Plasma concentration of some OP insecticides predicts outcome. The development of rapid bedside tests for OP detection may aid early assessment of severity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.