ArticlePharmacology, biochemistry, and behavior2008
Acute sensitivity and acute tolerance to ethanol in preweanling rats with or without prenatal experience with the drug.
Article in Pharmacology, biochemistry, and behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Prenatal Exposure to Low Alcohol and Alcohol Motivation in the Offspring.Advances in experimental medicine and biology · 2026Review
- Effect of Modulation of the Astrocytic Glutamate Transporters' Expression on Cocaine-Induced Reinstatement in Male P Rats Exposed to Ethanol.Alcohol and alcoholism (Oxford, Oxfordshire) · 2021Article
- Prenatal Alcohol Exposure as a Case of Involuntary Early Onset of Alcohol Use: Consequences and Proposed Mechanisms From Animal Studies.Frontiers in behavioral neuroscience · 2020Article
- Construction of vapor chambers used to expose mice to alcohol during the equivalent of all three trimesters of human development.Journal of visualized experiments : JoVE · 2014Article
- New evidence of ethanol's anxiolytic properties in the infant rat.Alcohol (Fayetteville, N.Y.) · 2014Article
- Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose.Alcohol (Fayetteville, N.Y.) · 2014Article
- Age-dependent effects of stress on ethanol-induced motor activity in rats.Psychopharmacology · 2013Article
- Ethanol-induced locomotor activity in adolescent rats and the relationship with ethanol-induced conditioned place preference and conditioned taste aversion.Developmental psychobiology · 2013Article
- Prenatal ethanol exposure increases ethanol intake and reduces c-Fos expression in infralimbic cortex of adolescent rats.Pharmacology, biochemistry, and behavior · 2013Article
- Prenatal ethanol exposure leads to greater ethanol-induced appetitive reinforcement.Alcohol (Fayetteville, N.Y.) · 2012Article
- Chronic tolerance to the locomotor stimulating effect of ethanol in preweanling rats as a function of social stress.Alcohol (Fayetteville, N.Y.) · 2012Article
- Early role of the κ opioid receptor in ethanol-induced reinforcement.Physiology & behavior · 2012Article
- Early maternal separation affects ethanol-induced conditioning in a nor-BNI insensitive manner, but does not alter ethanol-induced locomotor activity.Pharmacology, biochemistry, and behavior · 2012Article
- Mianserin, but not ondansetron, reduces the locomotor stimulating effect of ethanol in preweanling rats.Pharmacology, biochemistry, and behavior · 2011Article
- An acetaldehyde-sequestering agent inhibits appetitive reinforcement and behavioral stimulation induced by ethanol in preweanling rats.Pharmacology, biochemistry, and behavior · 2011Article
- Naloxone blocks ethanol-mediated appetitive conditioning and locomotor activation in adolescent rats.Behavioural brain research · 2011Article
- A comparison between taste avoidance and conditioned disgust reactions induced by ethanol and lithium chloride in preweanling rats.Developmental psychobiology · 2010Article
- Social isolation and stress related hormones modulate the stimulating effect of ethanol in preweanling rats.Behavioural brain research · 2010Article
- High ethanol dose during early adolescence induces locomotor activation and increases subsequent ethanol intake during late adolescence.Developmental psychobiology · 2010Article
- Differential role of mu, delta and kappa opioid receptors in ethanol-mediated locomotor activation and ethanol intake in preweanling rats.Physiology & behavior · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The present study examined behavioral sensitivity and acute tolerance to ethanol in infants with or without a moderate prenatal ethanol experience. During gestational days 17-20 dams received 0.0 or 2.0 g/kg ethanol. On postnatal day 13 pups were administered 0.0, 0.5 or 2.5 g/kg ethanol prior to assessment of locomotion. One third of the pups were evaluated at 5-10, 30-35 and 60-65 min after ethanol administration; another third was tested only during the last two post-administration periods; and the remaining third was tested only at 60-65 min. At 30-35 min blood ethanol levels were similar to those attained at 60-65 min. The main results of the study were: (a) The 2.5 g/kg ethanol dose induced biphasic motor effects: stimulation 5-10 min after drug administration and sedation after 30-35 or 60-65 min. (b) Infants exhibited acute tolerance to ethanol's sedative effects. (c) Although pups prenatally treated with ethanol exhibited heightened locomotor activity levels, acute sensitivity and tolerance were not affected by prenatal treatment. In summary, infants are sensitive to biphasic motor consequences of ethanol and readily exhibit acute tolerance to ethanol's sedative effects. In addition, moderate prenatal ethanol exposure was sufficient to induce hyper-reactivity in the offspring without affecting habituation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.