ArticleMolecular cell2008
MAP kinase-mediated c-fos regulation relies on a histone acetylation relay switch.
Article in Molecular cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 60 citations in OpenAlex.
- Increase of c-FOS promoter transcriptional activity by the dual leucine zipper kinase.Naunyn-Schmiedeberg's archives of pharmacology · 2023Article
- IL-1 Transcriptional Responses to Lipopolysaccharides Are Regulated by a Complex of RNA Binding Proteins.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Enhancer activation by FGF signalling during otic induction.Developmental biology · 2020Article
- ERCC6L that is up-regulated in high grade of renal cell carcinoma enhances cell viability in vitro and promotes tumor growth in vivo potentially through modulating MAPK signalling pathway.Cancer gene therapy · 2019Article
- Acute Stress Enhances Epigenetic Modifications But Does Not Affect the Constitutive Binding of pCREB to Immediate-Early Gene Promoters in the Rat Hippocampus.Frontiers in molecular neuroscience · 2017Article
- Jun-Mediated Changes in Cell Adhesion Contribute to Mouse Embryonic Stem Cell Exit from Ground State Pluripotency.Stem cells (Dayton, Ohio) · 2016Article
- Rapid deamination of cyclobutane pyrimidine dimer photoproducts at TCG sites in a translationally and rotationally positioned nucleosome in vivo.The Journal of biological chemistry · 2015Article
- Otx2 and Oct4 drive early enhancer activation during embryonic stem cell transition from naive pluripotency.Cell reports · 2014Article
- WDR5, ASH2L, and RBBP5 control the efficiency of FOS transcript processing.Cellular & molecular biology letters · 2014Article
- Making memories of stressful events: a journey along epigenetic, gene transcription, and signaling pathways.Frontiers in psychiatry · 2014Review
- Poly(ADP-ribosyl)ation is required to modulate chromatin changes at c-MYC promoter during emergence from quiescence.PloS one · 2014Article
- ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1.Nucleic acids research · 2013Article
- PARP1 orchestrates variant histone exchange in signal-mediated transcriptional activation.EMBO reports · 2013Article
- Nuclear Factor I genomic binding associates with chromatin boundaries.BMC genomics · 2013Article
- Regulation of c-Fos gene expression by NF-κB: a p65 homodimer binding site in mouse embryonic fibroblasts but not human HEK293 cells.PloS one · 2013Article
- The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism.Molecular and cellular biology · 2013Article
- Adhesion regulates MAP kinase/ternary complex factor exchange to control a proliferative transcriptional switch.Current biology : CB · 2012Article
- MicroRNA-9 Modulates Hes1 ultradian oscillations by forming a double-negative feedback loop.Cell reports · 2012Article
- EGF activates TTP expression by activation of ELK-1 and EGR-1 transcription factors.BMC molecular biology · 2012Article
- A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Gene activation is often associated with high levels of histone acetylation. Enhanced acetylation levels can promote the recruitment of further chromatin modifying complexes or the basal transcription machinery. Here, we have studied MAP kinase-mediated upregulation of c-fos and uncover a role for histone acetylation in promoting the recruitment of a second transcription factor, NFI. MAP kinase signaling to Elk-1 enhances the net histone acetylase activity associated with the c-fos promoter, which leads to changes in the acetylation state and structure of a promoter-proximal nucleosome, which allows NFI binding. Binding of NFI provides a permissive state for the recruitment of basal machinery and subsequent promoter activation. Our results provide insights into how MAP kinase signaling promotes inducible gene expression; phosphorylation of recipient transcription factors (primary effectors) triggers a HAT relay switch, which facilitates the recruitment of additional transcription factors (secondary effectors) through alteration of the local nucleosomal structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.