ArticleJournal of evaluation in clinical practice2008
Combined bias suppression in single-arm therapy studies.
Article in Journal of evaluation in clinical practice, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Promoting physical activity-related health competence to increase leisure-time physical activity and health-related quality of life in German private sector office workers.BMC public health · 2023Trial
- Rehabilitation therapy versus drug-only therapy in patients with multiple sclerosis.Turkish journal of medical sciences · 2024Observational
- The Early Initiation Advantages of Physical Therapy in Multiple Sclerosis-A Pilot Study.Life (Basel, Switzerland) · 2023Article
- Highlighting the Benefits of Rehabilitation Treatments in Hip Osteoarthritis.Medicina (Kaunas, Lithuania) · 2022Observational
- Validity and responsiveness of EQ-5D-5L and SF-6D in patients with health complaints attributed to their amalgam fillings: a prospective cohort study of patients undergoing amalgam removal.Health and quality of life outcomes · 2021Article
- Contributing to Global Health: Development of a Consensus-Based Whole Systems Research Strategy for Anthroposophic Medicine.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Overview of the Publications From the Anthroposophic Medicine Outcomes Study (AMOS): A Whole System Evaluation Study.Global advances in health and medicine · 2014Review
- Anthroposophic medicine: an integrative medical system originating in europe.Global advances in health and medicine · 2013Article
- Long-term outcomes of anthroposophic treatment for chronic disease: a four-year follow-up analysis of 1510 patients from a prospective observational study in routine outpatient settings.BMC research notes · 2013Observational
- Anthroposophic therapy for attention deficit hyperactivity: a two-year prospective study in outpatients.International journal of general medicine · 2010Article
- Predictors of outcome after 6 and 12 months following anthroposophic therapy for adult outpatients with chronic disease: a secondary analysis from a prospective observational study.BMC research notes · 2010Article
- Health costs in patients treated for depression, in patients with depressive symptoms treated for another chronic disorder, and in non-depressed patients: a two-year prospective cohort study in anthroposophic outpatient settings.The European journal of health economics : HEPAC : health economics in prevention and care · 2010Article
- Anthroposophic therapy for migraine: a two-year prospective cohort study in routine outpatient settings.The open neurology journal · 2010Article
- Anthroposophic therapy for asthma: A two-year prospective cohort study in routine outpatient settings.Journal of asthma and allergy · 2009Article
- Anthroposophic therapy for children with chronic disease: a two-year prospective cohort study in routine outpatient settings.BMC pediatrics · 2009Article
- Outcome of anthroposophic medication therapy in chronic disease: a 12-month prospective cohort study.Drug design, development and therapy · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RATIONALE, AIMS AND
objectivesFor therapy evaluation studies, control groups are sometimes not feasible. In single-arm studies, various bias factors apart from the test therapy can affect clinical outcomes. The objective of this analysis was to improve the methods to minimize bias in single-arm studies.
methodWe present a procedure for combined suppression of several bias factors, using two methods: sample restriction to patients unaffected by bias, and score adjustment. The procedure was used for a secondary analysis of disease score (doctors' global rating, 0-10) in a cohort of patients receiving anthroposophic therapies for chronic diseases. Four bias factors were suppressed stepwise: attrition bias (by replacing missing values with the baseline value carried forward), bias from natural recovery (by sample restriction to patients with disease duration of >/=12 months), regression to the mean due to symptom-driven self-selection (by replacing baseline scores with scores three months before enrolment) and bias from adjunctive therapies (by sample restriction to patients not using adjunctive therapies).
resultsIn the cohort analysed, these four bias factors could together explain a maximum of 37% of the 0- to 6-month improvement of disease score.
conclusionCombined bias suppression, using sample restriction and score adjustment, is a transparent procedure to minimize bias in single-arm therapy studies. Further applicability of the procedure should be tested in future studies.
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