Evidence map›Paper›PMID 18373523›Full record

ArticleMolecular microbiology2008

Small non-coding RNAs in Caulobacter crescentus.

Stephen G Landt, Eduardo Abeliuk, Patrick T McGrath, Joseph A Lesley, Harley H McAdams, Lucy Shapiro

Open access · bronzeAbstract read
In one paragraph

Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 102 citations in OpenAlex.

  1. Article
  2. Key players in regulatory RNA realm of bacteria.Biochemistry and biophysics reports · 2022
    Review
  3. Article
  4. Article
  5. Prevalence of small base-pairing RNAs derived from diverse genomic loci.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020
    Review
  6. Article
  7. Article
  8. Multilayered control of chromosome replication inBiochemical Society transactions · 2019
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Regulatory sRNAs in Cyanobacteria.Frontiers in microbiology · 2018
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. In silico prediction and qPCR validation of novel sRNAs inJournal, genetic engineering & biotechnology · 2016
    Article
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Stephen G LandtDepartment of Developmental Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Eduardo Abeliuk
Patrick T McGrath
Joseph A Lesley
Harley H McAdams
Lucy Shapiro
Stanford University · US

Funding

REGULATION OF DIFFERENTIATION IN CAULOBACTERR01GM032506 · NIGMS · YESHIVA UNIVERSITY · PI SHAPIRO, LUCILLE · 1985 to 2014
$7.1M
DEVELOPMENT CONTROL OF DNA REPLICATION IN CAULOBACTERR01GM051426 · NIGMS · STANFORD UNIVERSITY · PI SHAPIRO, LUCILLE · 1994 to 2013
$3.8M
REGULATION OF DIFFERENTIATION IN CAULOBACTERR37GM032506 · NIGMS · STANFORD UNIVERSITY · PI SHAPIRO, LUCILLE · 1993 to 2002
$1.4M
NIGMS NIH HHS GM32506NIGMS NIH HHS GM51426NIGMS NIH HHS R01 GM032506NIGMS NIH HHS R01 GM051426NIGMS NIH HHS R37 GM032506
6 · The paper itself

Abstract

Small non-coding RNAs (sRNAs) are active in many bacterial cell functions, including regulation of the cell's response to environmental challenges. We describe the identification of 27 novel Caulobacter crescentus sRNAs by analysis of RNA expression levels assayed using a tiled Caulobacter microarray and a protocol optimized for detection of sRNAs. The principal analysis method involved identification of sets of adjacent probes with unusually high correlation between the individual intergenic probes within the set, suggesting presence of a sRNA. Among the validated sRNAs, two are candidate transposase gene antisense RNAs. The expression of 10 of the sRNAs is regulated by either entry into stationary phase, carbon starvation, or rich versus minimal media. The expression of four of the novel sRNAs changes as the cell cycle progresses. One of these shares a promoter motif with several genes expressed at the swarmer-to-stalked cell transition; while another appears to be controlled by the CtrA global transcriptional regulator. The probe correlation analysis approach reported here is of general use for large-scale sRNA identification for any sequenced microbial genome.

Indexed as

Gene Expression Regulation, BacterialBase SequenceCaulobacter crescentusGenome, BacterialMolecular Sequence DataOligonucleotide Array Sequence AnalysisRNA, AntisenseRNA, BacterialRNA, UntranslatedTranscription, GeneticRNA, AntisenseRNA, BacterialRNA, Untranslated

Identifiers

PMID18373523
PMCPMC7540941
OpenAlexW2076770818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.