Evidence map›Paper›PMID 18373088›Full record

ArticleAnalytical and bioanalytical chemistry2008

Liquid chromatography-electrospray tandem mass spectrometry investigations of fragmentation pathways of biliary 4,4'-methylenedianiline conjugates produced in rats.

Kan Chen, Tammy R Dugas, Richard B Cole

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kan ChenDepartment of Chemistry, University of New Orleans, 2000 Lakeshore Dr., New Orleans, LA 70148, USA.
Tammy R Dugas
Richard B Cole
University of New Orleans · USLouisiana State University Health Sciences Center Shreveport · US

Funding

Molecular Mechanisms of Environmental InjuryT32ES007254 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI AMEREDES, BILL T · 1990 to 2022
$6.6M
THE VASCULAR TOXICITY OF 4,4 METHYLENE DIANILINEF32ES005892 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI DUGAS, TAMMY R · 1999 to 1999
–
METHYLENE DIANILINE--A SELECTIVE BILE DUCT TOXICANT?R01ES006348 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI KANZ, MARY F · 1995 to 1997
–
NIEHS NIH HHS 1F32 ES05892NIEHS NIH HHS ES06348NIEHS NIH HHS F32 ES005892NIEHS NIH HHS R01 ES006348NIEHS NIH HHS T32 ES007254NIEHS NIH HHS T32 ES07254
6 · The paper itself

Abstract

4,4'-methylenedianiline (DAPM) is the main building block for production of 4,4'-methylenediphenyldiisocyanate that has been widely used in the manufacturing of polyurethane materials including medical devices. Although it was revealed that damage to biliary epithelial cells of the liver and common bile duct occurred upon acute exposure to DAPM, the exact mechanism of DAPM toxicity is not fully understood. Both phase I and II biotransformations of DAPM, some of which generate reactive intermediates, are characterized in detail by liquid chromatography electrospray tandem mass spectrometry. The two most prominent metabolites found in rat bile (M2 and M7) implicated glutathione, glucuronic acid, and glycine conjugations (phase II) following hydroxylation, and N-oxidation (phase I). Their decomposition pathways, as evidenced by MS(n) experiments, have been elucidated in detail. [figure: see text]

Indexed as

Chromatography, LiquidSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryAniline CompoundsAnimalsBenzhydryl CompoundsBileBiotransformationGlucuronic AcidGlutathioneGlycineHydroxylationMolecular StructureRatsRats, Sprague-Dawley4,4'-diaminodiphenylmethaneAniline CompoundsBenzhydryl CompoundsGlucuronic AcidGlutathioneGlycine

Identifiers

PMID18373088
PMCPMC2819358
OpenAlexW2094498464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.