ArticleJournal of neuro-oncology2008
Two metachronous tumors induced by radiation therapy: case report and review of the literature.
Article in Journal of neuro-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Long-term outcomes of multimodality management for parasagittal meningiomas.Journal of neuro-oncology · 2020Article
- Metachronous translocation renal cell carcinoma in a child with successfully treated medulloblastoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Neural Axis Metastasis from Metachronous Pulmonary Basaloid Carcinoma Developed after Chemotherapy & Radiation Therapy of Uterine Cervical Carcinoma.Korean journal of neurotrauma · 2016Article
- Subcutaneous malignant melanoma of the scalp surgical flap after brain irradiation for anaplastic astrocytoma.Journal of neuro-oncology · 2012Article
- Radiation-induced cerebellar high-grade glioma accompanied by meningioma and cavernoma 29 years after the treatment of medulloblastoma: a case report.Journal of neuro-oncology · 2010Article
- Metachronous gliomas following cranial irradiation for mixed germ cell tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Article
- Metachronous medulloblastoma and glioblastoma: Implications for clinical and technical aspects of re-irradiation.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyArticle
- Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis.Neuro-oncology advancesReview
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various radiation-induced tumors, including meningioma, glioma, and sarcoma, have been reported; however, metachronous intracranial double tumors induced by radiation therapy are extremely rare. A 1-year-old boy had undergone tumor removal and craniospinal radiation therapy (30 Gy) for cerebellar medulloblastoma. At 24 years old, parasagittal meningioma developed in the left parietal region and was totally removed. Six years later, an infiltrative tumor was newly found in the right fronto-temporal white matter. The patient underwent stereotactic biopsy, and the tumor was found to be an anaplastic astrocytoma. Chromosomal analysis by fluorescence in situ hybridization (FISH) revealed loss of heterozygosity (LOH) of 1p. As the patient had previously had craniospinal irradiation, no additional radiation therapy was delivered. He underwent chemotherapy with temozolomide and the disease is now stable. Since both secondary tumors were located within the area of previous radiation and the patient did not have any genetic disease predisposing him to tumors, radiation therapy was considered to be responsible for their tumorigenesis. To our knowledge, this case is the fourth case of radiation-induced double CNS tumors arising after radiotherapy to be described in the literature. Whenever radiation is administered to children or young adults, careful serial screening studies are needed.
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