ArticleNeuron glia biology2007
Cytoskeletal transition at the paranodes: the Achilles' heel of myelinated axons.
Article in Neuron glia biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Protective effects of edaravone on white matter pathology in a novel mouse model of Alzheimer's disease with chronic cerebral hypoperfusion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Regulation and dysregulation of axon infrastructure by myelinating glia.The Journal of cell biology · 2017Review
- Axonal Membranes and Their Domains: Assembly and Function of the Axon Initial Segment and Node of Ranvier.Frontiers in cellular neuroscience · 2017Review
- Charcot-Marie-Tooth disease: New insights from skin biopsy.Neurology · 2015Article
- Organization and maintenance of molecular domains in myelinated axons.Journal of neuroscience research · 2013Review
- Alzheimer's disease as homeostatic responses to age-related myelin breakdown.Neurobiology of aging · 2011Review
- Comparing peripheral glial cell differentiation in Drosophila and vertebrates.Cellular and molecular life sciences : CMLS · 2011Review
- Axonal ensheathment and intercellular barrier formation in Drosophila.International review of cell and molecular biology · 2010Review
- Spatiotemporal ablation of myelinating glia-specific neurofascin (Nfasc NF155) in mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of axonal domains.Journal of neuroscience research · 2009Article
- The septate junction protein caspr is required for structural support and retention of KCNQ4 at calyceal synapses of vestibular hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Myelination and regional domain differentiation of the axon.Results and problems in cell differentiation · 2009Review
- No effect of genetic deletion of contactin-associated protein (CASPR) on axonal orientation and synaptic plasticity.Journal of neuroscience research · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Myelination organizes axons into distinct domains that allow nerve impulses to propagate in a saltatory manner. The edges of the myelin sheath are sealed at the paranodes by axon-glial junctions that have a crucial role in organizing the axonal cytoskeleton. Here we propose a model in which the myelinated axons depend on the axon-glial junctions to stabilize the cytoskeletal transition at the paranodes. Thus paranodal regions are likely to be particularly susceptible to damage induced by demyelinating diseases such as multiple sclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.