ArticleThe Journal of physiology2008
Brainstem modulation of locomotion in the neonatal mouse spinal cord.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks.Nature communications · 2023Article
- A review of the bioeffects of low-intensity focused ultrasound and the benefits of a cellular approach.Frontiers in physiology · 2022Review
- Sensory cortical control of movement.Nature neuroscience · 2020Article
- Influence of Brain Stem on Axial and Hindlimb Spinal Locomotor Rhythm Generating Circuits of the Neonatal Mouse.Frontiers in neuroscience · 2018Article
- Diversity of molecularly defined spinal interneurons engaged in mammalian locomotor pattern generation.Journal of neurophysiology · 2017Review
- Dopaminergic modulation of locomotor network activity in the neonatal mouse spinal cord.Journal of neurophysiology · 2015Article
- Enabling techniques for in vitro studies on mammalian spinal locomotor mechanisms.Frontiers in bioscience (Landmark edition) · 2012Review
- Organization of functional synaptic connections between medullary reticulospinal neurons and lumbar descending commissural interneurons in the neonatal mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Keeping it together: mechanisms of intersegmental coordination for a flexible locomotor behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Endogenous extracellular serotonin modulates the spinal locomotor network of the neonatal mouse.The Journal of physiology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During development, descending projections to the spinal cord are immature. Available data suggest that even though these projections are not fully formed, they contribute to activation of spinal circuitry and promote development of network function. Here we examine the modulation of sacrocaudal afferent-evoked locomotor activity by descending pathways. We first examined the effects of brainstem transection on the afferent evoked locomotor-like rhythm using an isolated brainstem-spinal cord preparation of the mouse. Transection increased the frequency and stability of the locomotor-like rhythm while the phase remained unchanged. We then made histologically verified lesions of the ventrolateral funiculus and observed similar effects on the stability and frequency of the locomotor rhythm. We next tested whether these effects were due to downstream effects of the transection. A split-bath was constructed between the brainstem and spinal cord. Neural activity was suppressed in the brainstem compartment using cooled high sucrose solutions. This manipulation led to a reversible change in frequency and stability that mirrored our findings using lesion approaches. Our findings suggest that spontaneous brainstem activity contributes to the ongoing modulation of afferent-evoked locomotor patterns during early postnatal development. Our work suggests that some of the essential circuits necessary to modulate and control locomotion are at least partly functional before the onset of weight-bearing locomotion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.