ArticleThe Journal of physiology2008
Restrictions in systemic and locomotor skeletal muscle perfusion, oxygen supply and VO2 during high-intensity whole-body exercise in humans.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Acute and Chronic Effects of Blood Flow Restricted High-Intensity Interval Training: A Systematic Review.Sports medicine - open · 2022Pooled it
- Impact of Pre-exercise Hypohydration on Aerobic Exercise Performance, Peak Oxygen Consumption and Oxygen Consumption at Lactate Threshold: A Systematic Review with Meta-analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
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- Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase.The Journal of physiology · 2017Trial
- Lactate recovery kinetics in response to high-intensity exercises.European journal of applied physiology · 2016Trial
- Effects of pre-exercise alkalosis on the decrease in VO2 at the end of all-out exercise.European journal of applied physiology · 2016Trial
- The distribution of blood flow in the carotid and vertebral arteries during dynamic exercise in humans.The Journal of physiology · 2011Trial
- An operational approach for estimating pulmonary diffusing capacity for oxygen in humans.Experimental physiology · 2026Article
- Importance of individual hemodynamic thresholds during exercise (Hem-TRex): relationship with blood pressure.Journal of human hypertension · 2026Article
- Muscle and cerebral oxygenation during exercise in fibromyalgia: a near-infrared spectroscopy study.European journal of applied physiology · 2026Article
- Increases in skin perfusion and blood oxygen in the non-exercising human limbs during exercise in the heat: Implications for control of circulation.Experimental physiology · 2025Article
- Targeting Myostatin as an Adjunct Treatment for the Preservation of Cardiometabolic and Skeletal Muscle Function in Type 1 Diabetes.International journal of molecular sciences · 2025Article
- The heart, a secondary organ in the control of blood circulation.Experimental physiology · 2025Review
- Reliability of hemodynamic parameters measured by bioimpedance cardiography at different intensities during incremental exercise testing.Frontiers in cardiovascular medicine · 2025Article
- Zone 2 Intensity: A Critical Comparison of Individual Variability in Different Submaximal Exercise Intensity Boundaries.Translational sports medicine · 2025Article
- On the mechanisms of stress-induced human spleen contraction: training for a higher blood oxygen-carrying capacity.European journal of applied physiology · 2024Review
- The Chinese cardiorespiratory and circulatory system at work in women and men: a case-control study.The Lancet regional health. Western Pacific · 2024Article
- The cardiovascular changes underlying a low cardiac output with exercise in patients with type 2 diabetes mellitus.Frontiers in physiology · 2024Review
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9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perfusion to exercising skeletal muscle is regulated to match O(2) delivery to the O(2) demand, but this regulation might be compromised during or approaching maximal whole-body exercise as muscle blood flow for a given work rate is blunted. Whether muscle perfusion is restricted when there is an extreme metabolic stimulus to vasodilate during supramaximal exercise remains unknown. To examine the regulatory limits of systemic and muscle perfusion in exercising humans, we measured systemic and leg haemodynamics, O(2) transport, and , and estimated non-locomotor tissue perfusion during constant load supramaximal cycling (498 +/- 16 W; 110% of peak power; mean +/- S.E.M.) in addition to both incremental cycling and knee-extensor exercise to exhaustion in 13 trained males. During supramaximal cycling, cardiac output (Q), leg blood flow (LBF), and systemic and leg O(2) delivery and reached peak values after 60-90 s and thereafter levelled off at values similar to or approximately 6% (P < 0.05) below maximal cycling, while upper body blood flow remained unchanged (approximately 5.5 l min(-1)). In contrast, Q and LBF increased linearly until exhaustion during one-legged knee-extensor exercise accompanying increases in non-locomotor tissue blood flow to approximately 12 l min(-1). At exhaustion during cycling compared to knee-extensor exercise, Q, LBF, leg vascular conductance, leg O(2) delivery and leg for a given power were reduced by 32-47% (P < 0.05). In conclusion, locomotor skeletal muscle perfusion is restricted during maximal and supramaximal whole-body exercise in association with a plateau in Q and limb vascular conductance. These observations suggest that limits of cardiac function and muscle vasoconstriction underlie the inability of the circulatory system to meet the increasing metabolic demand of skeletal muscles and other tissues during whole-body exercise.
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Registered trials
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