ArticleGene2008
Global gene expression analysis reveals specific and redundant roles for H1 variants, H1c and H1(0), in gene expression regulation.
Article in Gene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Linker histone H1.5 contributes to centromere integrity.Nucleic acids research · 2026Article
- Heterologous expression of bovine histone H1foo into porcine fibroblasts alters the transcriptome profile but not embryo development following nuclear transfer.Journal of assisted reproduction and genetics · 2025Article
- Histone variants in skeletal myogenesis.Epigenetics · 2021Review
- Significance of avian linker histone (H1) polymorphic variation.Journal of biosciences · 2018Review
- H1.0 Linker Histone as an Epigenetic Regulator of Cell Proliferation and Differentiation.Genes · 2018Review
- LASP1-S100A11 axis promotes colorectal cancer aggressiveness by modulating TGFβ/Smad signaling.Scientific reports · 2016Article
- Photobleaching studies reveal that a single amino acid polymorphism is responsible for the differential binding affinities of linker histone subtypes H1.1 and H1.5.Biology open · 2016Article
- Nuclear and nucleolar activity of linker histone variant H1.0.Cellular & molecular biology letters · 2016Review
- HP1BP3 is a novel histone H1 related protein with essential roles in viability and growth.Nucleic acids research · 2015Article
- What is the role of histone H1 heterogeneity? A functional model emerges from a 50 year mystery.AIMS biophysics · 2015Article
- Mapping of six somatic linker histone H1 variants in human breast cancer cells uncovers specific features of H1.2.Nucleic acids research · 2014Article
- High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.The Journal of biological chemistry · 2013Article
- N- and C-terminal domains determine differential nucleosomal binding geometry and affinity of linker histone isotypes H1(0) and H1c.The Journal of biological chemistry · 2012Article
- Effects of HMGN variants on the cellular transcription profile.Nucleic acids research · 2011Article
- Article
- Transcriptome analysis of functional differentiation between haploid and diploid cells of Emiliania huxleyi, a globally significant photosynthetic calcifying cell.Genome biology · 2009Article
- Depletion of human histone H1 variants uncovers specific roles in gene expression and cell growth.PLoS genetics · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In mammals, the functional significance of the presence of evolutionarily conserved, multiple non-allelic H1 variants remains unclear. We used a unique overproduction approach coupled with cell cycle synchronization and early time point assays to assess differential effects of H1 variants, H1c and H1(0), on global gene expression in the absence of compensatory events that may mask variant-specific effects. We found that H1c and H1(0) act primarily as specific rather than global regulators of gene expression. Many of the genes affected were uniquely targeted by either H1c or H1(0), affirming that H1 variants have some unique roles. We also identified genes that were affected by both variants, in which cases the expression of these genes was, for the most part, affected similarly by both the variants. This observation suggests that as well as having specific functions, the H1 variants share common roles in the organization of chromatin. We further noted that H1(0) repressed more genes than did H1c, which may underlie the prevailing notion that H1(0) is a stronger repressor of transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.