ArticleBrain research2008
Dopamine receptor gene expression in human amygdaloid nuclei: elevated D4 receptor mRNA in major depression.
Article in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Postmortem evidence of decreased brain pH in major depressive disorder: a systematic review and meta-analysis.Translational psychiatry · 2024Pooled it
- Zishen pingchan granules combined with pramipexole in the improvement of depressive symptoms in Parkinson's disease: a prospective, multicenter, randomized, double-blind, controlled clinical study.Journal of translational medicine · 2022Trial
- Therapeutic potential ofIn silico pharmacology · 2026Article
- Seizures associated with clozapine augmentation by other antipsychotics: a pharmacovigilance-pharmacodynamic analysis using VigiBase.Therapeutic advances in psychopharmacology · 2026Article
- Hycanthone Inhibits Inflammasome Activation and Neuroinflammation-Induced Depression-Like Behaviors in Mice.Biomolecules & therapeutics · 2023Article
- Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?Frontiers in pharmacology · 2022Review
- Preliminary Pharmacogenetic Study to Explore Putative Dopaminergic Mechanisms of Antidepressant Action.Journal of personalized medicine · 2021Article
- Association of DRD4 exon III and 5-HTTLPR VNTR genetic polymorphisms with psychiatric symptoms in hemodialysis patients.PloS one · 2021Article
- Unravelling the interaction between theBMJ open sport & exercise medicine · 2019Article
- Basolateral amygdala volume and cell numbers in major depressive disorder: a postmortem stereological study.Brain structure & function · 2016Article
- Peer Victimization and DRD4 Genotype Influence Problem Behaviors in Young Children.Journal of youth and adolescence · 2015Article
- Homology modeling, molecular dynamic simulation, and docking based binding site analysis of human dopamine (D4) receptor.Journal of molecular modeling · 2015Article
- NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder.Molecular autism · 2015Article
- Sustained increase of PKA activity in the postcommissural putamen of dyskinetic monkeys.Molecular neurobiology · 2014Article
- Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia: A Pilot Study.Depression research and treatment · 2014Article
- Gene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder.Journal of psychiatry & neuroscience : JPN · 2013Article
- A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs.Behavioral and brain functions : BBF · 2012Article
- The influence of dopamine receptor d4 polymorphism on resting EEG in healthy young females.The open neuroimaging journal · 2012Article
- Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala.Molecular psychiatry · 2011Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Previous findings from this laboratory demonstrating changes in dopamine (DA) transporter and D2 receptors in the amygdaloid complex of subjects with major depression indicate that disruption of dopamine neurotransmission to the amygdala may contribute to behavioral symptoms associated with depression. Quantitative real-time RT-PCR was used to investigate the regional distribution of gene expression of DA receptors in the human amygdala. In addition, relative levels of mRNA of DA receptors in the basal amygdaloid nucleus were measured postmortem in subjects with major depression and normal control subjects. All five subtypes of DA receptor mRNA were detected in all amygdaloid subnuclei, although D1, D2, and D4 receptor mRNAs were more abundant than D3 and D5 mRNAs by an order of magnitude. The highest level of D1 mRNA was found in the central nucleus, whereas D2 mRNA was the most abundant in the basal nucleus. Levels of D4 mRNA were highest in the basal and central nuclei. In the basal nucleus, amounts of D4, but not D1 or D2, mRNAs were significantly higher in subjects with major depression as compared to control subjects. These findings demonstrate that the D1, D2 and D4 receptors are the major subtypes of DA receptors in the human amygdala. Elevated DA receptor gene expression in depressive subjects further implicates altered dopaminergic transmission in the amygdala in depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.