ArticleAmerican journal of human genetics2008
A Bayesian evaluation of human mitochondrial substitution rates.
Article in American journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Mitochondrial clone tracing within spatially intact human tissues.bioRxiv : the preprint server for biology · 2025Article
- Phylogeography, taxonomy, and conservation of the endangered brown howler monkey,Frontiers in genetics · 2024Article
- Review
- Variation in the Substitution Rates among the Human Mitochondrial Haplogroup U Sublineages.Genome biology and evolution · 2022Article
- Forensic Feature Exploration and Comprehensive Genetic Insights Into Yugu Ethnic Minority and Northern Han PopulationFrontiers in genetics · 2022Article
- Ancient DNA reveals multiple origins and migration waves of extinct Japanese brown bear lineages.Royal Society open science · 2021Article
- Ancient mitochondrial genomes from the Argentinian Pampas inform the early peopling of the Southern Cone of South America.iScience · 2021Article
- Molecular dating for phylogenies containing a mix of populations and species by using Bayesian and RelTime approaches.Molecular ecology resources · 2021Article
- Cattle mitogenome variation reveals a post-glacial expansion of haplogroup P and an early incorporation into northeast Asian domestic herds.Scientific reports · 2020Article
- Is Malaysia's banded langur, Presbytis femoralis femoralis, actually Presbytis neglectus neglectus? Taxonomic revision with new insights on the radiation history of the Presbytis species group in Southeast Asia.Primates; journal of primatology · 2019Article
- Demographic History of the Genus Pan Inferred from Whole Mitochondrial Genome Reconstructions.Genome biology and evolution · 2016Article
- Evaluating the Phylogenetic Status of the Extinct Japanese Otter on the Basis of Mitochondrial Genome Analysis.PloS one · 2016Article
- Phylogeographic and Demographic Analysis of the Asian Black Bear (Ursus thibetanus) Based on Mitochondrial DNA.PloS one · 2015Article
- Demographic History of Indigenous Populations in Mesoamerica Based on mtDNA Sequence Data.PloS one · 2015Article
- Improved calibration of the human mitochondrial clock using ancient genomes.Molecular biology and evolution · 2014Article
- The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents.BMC evolutionary biology · 2014Article
- Selecting optimal partitioning schemes for phylogenomic datasets.BMC evolutionary biology · 2014Article
- Large-scale mitochondrial DNA analysis in Southeast Asia reveals evolutionary effects of cultural isolation in the multi-ethnic population of Myanmar.BMC evolutionary biology · 2014Article
- Contrasting demographic histories of the neighboring bonobo and chimpanzee.Primates; journal of primatology · 2014Article
- Purifying selection causes widespread distortions of genealogical structure on the human X chromosome.Genetics · 2013Article
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2 authors.
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Abstract
Accurate estimates of mitochondrial substitution rates are central to molecular studies of human evolution, but meaningful comparisons of published studies are problematic because of the wide range of methodologies and data sets employed. These differences are nowhere more pronounced than among rates estimated from phylogenies, genealogies, and pedigrees. By using a data set comprising mitochondrial genomes from 177 humans, we estimate substitution rates for various data partitions by using Bayesian phylogenetic analysis with a relaxed molecular clock. We compare the effect of multiple internal calibrations with the customary human-chimpanzee split. The analyses reveal wide variation among estimated substitution rates and divergence times made with different partitions and calibrations, with evidence of substitutional saturation, natural selection, and significant rate heterogeneity among lineages and among sites. Collectively, the results support dates for migration out of Africa and the common mitochondrial ancestor of humans that are considerably more recent than most previous estimates. Our results also demonstrate that human mitochondrial genomes exhibit a number of molecular evolutionary complexities that necessitate the use of sophisticated analytical models for genetic analyses.
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