ArticleBrain pathology (Zurich, Switzerland)2008
Comprehensive characterization of genomic aberrations in gangliogliomas by CGH, array-based CGH and interphase FISH.
Article in Brain pathology (Zurich, Switzerland), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 69 citations in OpenAlex.
- VOPP1::EGFR fusion is associated with NFκB pathway activation in a glioneural tumor with histological features of ganglioglioma.Acta neuropathologica communications · 2025Article
- Data-driven information extraction and enrichment of molecular profiling data for cancer cell lines.Bioinformatics advances · 2024Article
- Benign Spinal Tumors.Advances in experimental medicine and biology · 2023Article
- Classification of Pediatric Gangliogliomas Based on the Histological Infiltration.Current oncology (Toronto, Ont.) · 2022Article
- Integrated genotype-phenotype analysis of long-term epilepsy-associated ganglioglioma.Brain pathology (Zurich, Switzerland) · 2022Article
- Polymorphous Low-Grade Neuroepithelial Tumor of the Young (PLNTY): Molecular Profiling Confirms Frequent MAPK Pathway Activation.Journal of neuropathology and experimental neurology · 2021Article
- Assessment of genetic variant burden in epilepsy-associated brain lesions.European journal of human genetics : EJHG · 2019Article
- An unusual recurrent high-grade glioneuronal tumor with MAP2K1 mutation and CDKN2A/B homozygous deletion.Acta neuropathologica communications · 2019Article
- H3F3A-G34R mutant high grade neuroepithelial neoplasms with glial and dysplastic ganglion cell components.Acta neuropathologica communications · 2019Article
- Pathologic and molecular aspects of anaplasia in circumscribed gliomas and glioneuronal tumors.Brain tumor pathology · 2019Review
- Grading Gangliogliomas: a Short Case Series With Clinico-Imagistic and Immunohistopathological Correlations.Maedica · 2018Article
- Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma.Brain pathology (Zurich, Switzerland) · 2018Article
- Cerebellar Ganglioglioma in Childhood: Histopathologic Implications for Management During Long-term Survival: A Case Report.Yonago acta medica · 2017Article
- A neuropathology-based approach to epilepsy surgery in brain tumors and proposal for a new terminology use for long-term epilepsy-associated brain tumors.Acta neuropathologica · 2014Review
- Pediatric low-grade gliomas: how modern biology reshapes the clinical field.Biochimica et biophysica acta · 2014Review
- Epilepsy related to developmental tumors and malformations of cortical development.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Review
- Constitutional tandem duplication of 9q34 that truncates EHMT1 in a child with ganglioglioma.Pediatric blood & cancer · 2012Article
- Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas.Brain pathology (Zurich, Switzerland) · 2011Article
- Article
- Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall.Acta neuropathologica · 2010Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gangliogliomas are generally benign neuroepithelial tumors composed of dysplastic neuronal and neoplastic glial elements. We screened 61 gangliogliomas [World Health Organization (WHO) grade I] for genomic alterations by chromosomal and array-based comparative genomic hybridization (CGH). Aberrations were detected in 66% of gangliogliomas (mean +/- SEM = 2.5 +/- 0.5 alterations/tumor). Frequent gains were on chromosomes 7 (21%), 5 (16%), 8 (13%), 12 (12%); frequent losses on 22q (16%), 9 (10%), 10 (8%). Recurrent partial imbalances comprised the minimal overlapping regions dim(10)(q25) and enh(12)(q13.3-q14.1). Unsupervised cluster analysis of genomic profiles detected two major subgroups (group I: complete gain of 7 and additional gains of 5, 8 or 12; group II: no major recurring imbalances, mainly losses). A comparison with low-grade gliomas (astrocytomas WHO grade II) showed chromosome 5 gain to be significantly more frequent in gangliogliomas. Interphase fluorescence in situ hybridization (FISH) identified the aberrations to be contained in a subpopulation of glial but not in neuronal cells. Two gangliogliomas and their anaplastic recurrences (WHO grade III) were analyzed. Losses of CDKN2A/B and DMBT1 or a gain/amplification of CDK4 found in the anaplastic tumors were already present in the respective gangliogliomas by array CGH and interphase FISH. In summary, genomic profiling in a large series of gangliogliomas could distinguish genetic subgroups even in this low-grade tumor.
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