Trial reportAcademic emergency medicine : official journal of the Society for Academic Emergency Medicine2008
Comparison of nebulized epinephrine to albuterol in bronchiolitis.
Trial report in Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Bronchodilators for bronchiolitis.The Cochrane database of systematic reviews · 2014Pooled it
- Epinephrine for bronchiolitis.The Cochrane database of systematic reviews · 2011Pooled it
- Bronchiolitis.BMJ clinical evidence · 2011Pooled it
- Prospective Multicentre Study on the Epidemiology and Current Therapeutic Management of Severe Bronchiolitis in Spain.BioMed research international · 2017Trial
- A Randomized Placebo Controlled Trial of Ibuprofen for Respiratory Syncytial Virus Infection in a Bovine Model.PloS one · 2016Trial
- Low-dose intrapulmonary drug delivery device for studies on next-generation therapeutics in mice.Journal of controlled release : official journal of the Controlled Release Society · 2023Article
- Validating a bovine model for lung ultrasound of bronchiolitis.Journal of ultrasound · 2022Article
- Which ICD-9-CM codes should be used for bronchiolitis research?BMC medical research methodology · 2018Article
- Even the Thinnest Salami Contains Some Meat.The western journal of emergency medicine · 2018Article
- Publishing Trends in the Field of Pediatric Emergency Medicine From 2004 to 2013.Pediatric emergency care · 2016Article
- Derivation of Candidate Clinical Decision Rules to Identify Infants at Risk for Central Apnea.Pediatrics · 2015Observational
- American Academy of Pediatrics 2014 bronchiolitis guidelines: bonfire of the evidence.The western journal of emergency medicine · 2015Article
- Comparison of epinephrine to salbutamol in acute bronchiolitis.Iranian journal of pediatrics · 2012Article
- Emergency Department Septic Screening in Respiratory Syncytial Virus (RSV) and Non-RSV Bronchiolitis.The western journal of emergency medicine · 2010Article
- Prevalence of Bordetella pertussis and Bordetella parapertussis in Samples Submitted for RSV Screening.The western journal of emergency medicine · 2008Article
- Intubations and airway management: An overview of Hassles through third millennium.Journal of emergencies, trauma, and shockArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare the effect of nebulized racemic epinephrine to nebulized racemic albuterol on successful discharge from the emergency department (ED).
methodsChildren up to their 18th month of life presenting to two teaching hospital EDs with a clinical diagnosis of bronchiolitis who were ill enough to warrant treatment but did not need immediate intubation were eligible for this double-blind randomized controlled trial (RCT). Patients received either three doses of racemic albuterol or one dose of racemic epinephrine plus two saline nebulizers. Disposition was decided 2 hours after the first nebulizer. Successful discharge was defined as not requiring additional bronchodilators in the ED after study drug administration and not subsequently admitted within 72 hours. Adjusted relative risks (aRR) were estimated using the modified Poisson regression with successful discharge as the dependent variable and study drug and severity of illness as exposures. Secondary analysis was performed for patients aged less than 12 months and first presentation.
resultsThe authors analyzed 703 patients; 352 patients were given albuterol and 351 epinephrine. A total of 173 in the albuterol group and 160 in the epinephrine group were successfully discharged (crude RR = 1.08, 95% confidence interval [CI] = 0.92 to 1.26). When adjusted for severity of illness, patients who received albuterol were significantly more likely than patients receiving epinephrine to be successfully discharged (aRR = 1.18, 95% CI = 1.02 to 1.36). This was also true among those with first presentation and in those less than 12 months of age.
conclusionsIn children up to the 18th month of life, ED treatment of bronchiolitis with nebulized racemic albuterol led to more successful discharges than nebulized epinephrine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.