ArticleClinical drug investigation1997
Effect of pentoxifylline in vitro on neutrophil reactive oxygen production and phagocytic ability assessed by flow cytometry.
Article in Clinical drug investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Role of pentoxifylline and sparfloxacin in prophylaxis of spontaneous bacterial peritonitis in cirrhotic patients.ISRN gastroenterology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophil granulocytes have been described as agents of defence and destruction. The effect of pentoxifylline on the phagocytic ability and generation of reactive oxygen radicals of neutrophils was studied at concentrations of 1, 10 and 100 mg/L. Flow cytometry was used to study phagocytic ability by measuring uptake of fluorescein-labelled bacteria. The generation of reactive oxygen intermediates was estimated by the quantification of the intracellular conversion of dihydrorhodamine 123 to rhodamine 123. In vitro pentoxifylline treatment diminished neutrophil reactive oxygen production (at 10 mg/L -45% and at 100 mg/L -63%; p < 0.001 for both) and reduced neutrophil phagocytic ability (at 100 mg/L -23%; p < 0.05). Both effects were rapidly reversible after plasma exchange. We conclude that pentoxifylline could decrease oxidative tissue damage by neutrophils in septicaemia or after IV granulocyte transfusion.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.