ArticlePituitary2009
Alterations in body composition in acromegaly.
Article in Pituitary, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 77 citations in OpenAlex.
- Evaluation of temporal muscle thickness in subjects with acromegaly: a follow-up study.Therapeutic advances in endocrinology and metabolism · 2026Article
- Static and Dynamic Balance Is Impaired in Patients With Long-Term, Well-Controlled Acromegaly: A Cross-Sectional Study.Clinical endocrinology · 2025Article
- Body mass index and metabolic complications in individuals with treatment-naïve acromegaly.Endocrine journal · 2025Article
- Assessment of sarcopenic obesity in patients with acromegaly.Pituitary · 2025Observational
- Assessment of forearm muscles with ultrasound shear wave elastography in patients with acromegaly.Pituitary · 2023Article
- Leukocyte Telomere Length and Neuregulin-4 Levels in Female Patients with Acromegaly: The Relationship between Disease Activity and Body Fat Distribution.Journal of clinical medicine · 2023Article
- Article
- Skeletal complications in acromegaly.Reumatologia · 2023Review
- Corneal Tonometric and Morphological Changes in Patients with Acromegaly.Journal of clinical medicine · 2022Article
- Changes in Cross-Sectional Area of the Median Nerve and Body Composition Parameters after Treatment of Acromegaly: 1 year Follow-Up.International journal of endocrinology · 2022Article
- Body Composition in Acromegaly According to Disease Activity - Performance of Dual X-Ray Absorptiometry and Multifrequency Bioelectrical Impedance Analysis.Frontiers in endocrinology · 2022Article
- Influence of Disease Activity and Body Composition Parameters on Cross-Sectional Area of the Median Nerve in Acromegalic Patients.Physiological research · 2021Article
- Neuromuscular Blockade Correlates with Hormones and Body Composition in Acromegaly.International journal of endocrinology · 2020Article
- Static and dynamic balances of patients with acromegaly and impact of exercise on balance.Pituitary · 2019Article
- Review
- Dynamic changes in the distribution of facial and abdominal adipose tissue correlated with surgical treatment in acromegaly.Endocrine · 2018Article
- Pre- and Postoperative Body Composition and Metabolic Characteristics in Patients with Acromegaly: A Prospective Study.International journal of endocrinology · 2018Article
- Pegvisomant in acromegaly: an update.Journal of endocrinological investigation · 2017Review
- Altered structure and function of adipose tissue in long-lived mice with growth hormone-related mutations.Adipocyte · 2017Review
- Altered somatotroph feedback regulation improves metabolic efficiency and limits adipose deposition in male mice.Metabolism: clinical and experimental · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acromegaly is a condition characterized by growth hormone (GH) and insulin-like growth factor-1 (IGF-1) hypersecretion, and is associated with boney overgrowth, and soft tissue abnormalities due to anabolic, lipolytic, and sodium retaining actions of GH. GH and IGF-1 excess is associated with alterations in body composition, including an increase in body water and lean body mass, and a reduction in body fat. Achievement of biochemical control of the disease results in a reduction in body water and fat-free mass, and an increase in body fat. BMD is generally increased in acromegaly, though the anabolic effect of GH excess on bone is reduced, if not negated, by the presence of hypogonadism, particularly with regard to the trabecular compartment. Further studies are necessary to determine the effect of long-term biochemical control on bone density in subjects with acromegaly.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.