ArticleJournal of neuro-oncology2008
Atypical teratoid rhabdoid tumor (AT/RT) in adults: review of four cases.
Article in Journal of neuro-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Atypical teratoid/rhabdoid tumor in adults: a systematic review of the literature with meta-analysis and additional reports of 4 cases.Journal of neuro-oncology · 2022Pooled it
- Radiological image features of the atypical teratoid/rhabdoid tumor in adults: a systematic review.Clinical neuroradiology · 2015Pooled it
- Oral malignant melanoma with rhabdoid cell differentiation and myogenic features in a dog.The Journal of veterinary medical science · 2026Article
- SMARCB1-related schwannomatosis and other SMARCB1-associated phenotypes: clinical spectrum and molecular pathogenesis.Familial cancer · 2025Review
- Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors.Genome biology · 2024Article
- Two Cases of Atypical Teratoid/Rhabdoid Tumor in the Spinal Cord: Loss of SMARCB1 in a Child and Loss of SMARCA4 in an Adult.NMC case report journal · 2024Article
- Atypical Teratoid Rhabdoid Tumor: Proposal of a Diagnostic Pathway Based on Clinical Features and Neuroimaging Findings.Diagnostics (Basel, Switzerland) · 2023Review
- Maternal embryonal leucine zipper kinase immunoreactivity in atypical teratoid/rhabdoid tumors: a study of 50 cases.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Dural-based atypical teratoid/rhabdoid tumor in an adult: DNA methylation profiling as a tool for the diagnosis.CNS oncology · 2020Article
- Fulminant presentation of a SMARCB1-deficient, anterior cranial fossa tumor in adult.Surgical neurology international · 2020Article
- A Systematic Review of Atypical Teratoid Rhabdoid Tumor in Adults.Frontiers in oncology · 2018Article
- Primary intracerebral INI1-deficient rhabdoid tumor with CD34 immunopositivity in a young adult.Surgical neurology international · 2018Article
- Glioma Subclassifications and Their Clinical Significance.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Atypical Teratoid/ Rhabdoid Tumor of Brain: a Clinicopathologic Study of Eleven Patients and Review of LiteratureAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Atypical Teratoid Rhabdoid Tumor: Two Case Reports and an Analysis of Adult Cases with Implications for Pathophysiology and Treatment.Frontiers in neurology · 2017Article
- Long-term survival following additive radiotherapy in patients with atypical teratoid rhabdoid tumors.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2016Article
- Atypical teratoid/rhabdoid tumor (ATRT) arising from the 3rd cranial nerve in infants: a clinical-radiological entity?Journal of neuro-oncology · 2015Article
- Adult-onset sellar and suprasellar atypical teratoid rhabdoid tumor treated with a multimodal approach: a case report.Brain tumor research and treatment · 2014Article
- Atypical teratoid/rhabdoid tumor in sellar turcica in an adult: A case report and review of the literature.Surgical neurology international · 2014Article
- Temporal lobe atypical teratoid/ rhabdoid tumor in a 24-year old adult female.South Asian journal of cancer · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atypical teratoid/rhabdoid (AT/RT) tumor is a rare, highly malignant tumor of the central nervous system (CNS) most commonly found in children less than 5 years of age. Although the vast majority of cases are diagnosed in young children, there have been isolated case reports in adults. Since its histological appearance can be confused with other tumors, especially in adults, separating AT/RT from other neoplasms may be difficult. In many instances, a reliable diagnosis is not possible without demonstrating the lack of nuclear INI1 protein expression by immunohistochemical methods. The patients (three males and one female) ranged in age from 23 to 42 years (mean age, 32 years). Radiographically, two tumors were localized in the right fronto-parietal region, one was frontal and the other was found in the left temporal lobe. Varying degrees of hydrocephalus and heterogeneous enhancement were present on MRI. In all cases, diagnosis during intraoperative consultation and preliminary diagnosis was different from the final diagnosis after immunohistochemical analysis. Immunohistochemical staining showed that the tumor cells were positive for vimentin and reacted variably for keratin, epithelial membrane antigen (EMA), synaptophysin, neurofilament protein, CD34, and smooth muscle actin (SMA). All were negative for GFAP, S-100, desmin and CD99. Three of the four cases lacked nuclear expression of INI1. One patient is alive with no evidence of disease 17 years after the diagnosis. In adult examples of AT/RT, the diagnosis requires a high index of suspicion, with early tissue diagnosis and a low threshold for investigation with INI1 immunohistochemistry to differentiate this entity from other morphologically similar tumors. Although the prognosis is dismal in pediatric population, long term survival is possible in adult AT/RT cases after surgery and adjuvant radiotherapy and chemotherapy.
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