ArticlePLoS pathogens2008
The effect of immune selection on the structure of the meningococcal opa protein repertoire.
Article in PLoS pathogens, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Diversity and evolution of a phase-variable multi-locus antigen in Neisseria gonorrhoeae.PLoS pathogens · 2026Article
- Diversity and evolution of a phase-variable multi-locus antigen inbioRxiv : the preprint server for biology · 2026Article
- Detecting co-selection through excess linkage disequilibrium in bacterial genomes.NAR genomics and bioinformatics · 2024Article
- Microevolution and Its Impact on Hypervirulence, Antimicrobial Resistance, and Vaccine Escape inMicroorganisms · 2023Review
- Gut immune responses and evolution of the gut microbiome-a hypothesis.Discovery immunology · 2023Review
- Reverse immunodynamics: a new method for identifying targets of protective immunity.Scientific reports · 2019Article
- Models of immune selection for multi-locus antigenic diversity of pathogens.Nature reviews. Immunology · 2019Review
- Transcriptomic buffering of cryptic genetic variation contributes to meningococcal virulence.BMC genomics · 2017Article
- Metabolic shift in the emergence of hyperinvasive pandemic meningococcal lineages.Scientific reports · 2017Article
- Diverse evolutionary patterns of pneumococcal antigens identified by pangenome-wide immunological screening.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Positive Selection Pressure Drives Variation on the Surface-Exposed Variable Proteins of the Pathogenic Neisseria.PloS one · 2016Article
- MANTIS: an R package that simulates multilocus models of pathogen evolution.BMC bioinformatics · 2015Article
- Contrasting within- and between-host immune selection shapes Neisseria Opa repertoires.Scientific reports · 2014Article
- Use of a molecular decoy to segregate transport from antigenicity in the FrpB iron transporter from Neisseria meningitidis.PloS one · 2013Article
- Persistence of hyperinvasive meningococcal strain types during global spread as recorded in the PubMLST database.PloS one · 2012Article
- Comparative genome biology of a serogroup B carriage and disease strain supports a polygenic nature of meningococcal virulence.Journal of bacteriology · 2010Article
- Review of meningococcal group B vaccines.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2010Review
- Accelerated microevolution in an outer membrane protein (OMP) of the intracellular bacteria Wolbachia.BMC evolutionary biology · 2010Article
- The modular architecture of meningococcal factor H-binding protein.Microbiology (Reading, England) · 2009Article
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The opa genes of the Gram negative bacterium Neisseria meningitidis encode Opacity-associated outer membrane proteins whose role is to promote adhesion to the human host tissue during colonisation and invasion. Each meningococcus contains 3-4 opa loci, each of which may be occupied by one of a large number of alleles. We analysed the Opa repertoire structure in a large, well-characterised collection of asymptomatically carried meningococci. Our data show an association between Opa repertoire and meningococcal lineages similar to that observed previously for meningococci isolated from cases of invasive disease. Furthermore, these Opa repertoires exhibit discrete, non-overlapping structure at a population level, and yet low within-repertoire diversity. These data are consistent with the predictions of a mathematical model of strong immune selection upon a system where identical alleles may occupy different loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.