ArticlePLoS genetics2008
An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans.Developmental cell · 2024Article
- Identification of miRNAs of Strongyloides stercoralis L1 and iL3 larvae isolated from human stool.Scientific reports · 2022Article
- Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior.eLife · 2021Article
- MIP-T3 Expression Associated with Defects of Ciliogenesis in Airway of COPD Patients.Canadian respiratory journal · 2020Article
- Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC-1 and BORC complexes.Developmental neurobiology · 2018Review
- IFT54 regulates IFT20 stability but is not essential for tubulin transport during ciliogenesis.Cellular and molecular life sciences : CMLS · 2017Article
- Partial uniparental isodisomy of chromosome 16 unmasks a deleterious biallelic mutation in IFT140 that causes Mainzer-Saldino syndrome.Human genomics · 2017Article
- Proteomic responses to elevated ocean temperature in ovaries of the ascidianBiology open · 2017Article
- The T cell IFT20 interactome reveals new players in immune synapse assembly.Journal of cell science · 2017Article
- Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases.Genes · 2017Review
- DISC1 is a coordinator of intracellular trafficking to shape neuronal development and connectivity.The Journal of physiology · 2016Review
- Ulk4 Is Essential for Ciliogenesis and CSF Flow.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin-binding IFT-B2 complex.The EMBO journal · 2016Article
- Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): implications for mental illness.Biology open · 2015Article
- Recurrent CNVs and SNVs at the NPHP1 locus contribute pathogenic alleles to Bardet-Biedl syndrome.American journal of human genetics · 2014Article
- Article
- Compartments within a compartment: what C. elegans can tell us about ciliary subdomain composition, biogenesis, function, and disease.Organogenesis · 2014Review
- Phosphoproteomics-mediated identification of Fer kinase as a target of mutant Shp2 in Noonan and LEOPARD syndrome.PloS one · 2014Article
- Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes.Nature communications · 2013Article
- Architecture and function of IFT complex proteins in ciliogenesis.Differentiation; research in biological diversity · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 3 countries.
Funding
Abstract
MIP-T3 is a human protein found previously to associate with microtubules and the kinesin-interacting neuronal protein DISC1 (Disrupted-in-Schizophrenia 1), but whose cellular function(s) remains unknown. Here we demonstrate that the C. elegans MIP-T3 ortholog DYF-11 is an intraflagellar transport (IFT) protein that plays a critical role in assembling functional kinesin motor-IFT particle complexes. We have cloned a loss of function dyf-11 mutant in which several key components of the IFT machinery, including Kinesin-II, as well as IFT subcomplex A and B proteins, fail to enter ciliary axonemes and/or mislocalize, resulting in compromised ciliary structures and sensory functions, and abnormal lipid accumulation. Analyses in different mutant backgrounds further suggest that DYF-11 functions as a novel component of IFT subcomplex B. Consistent with an evolutionarily conserved cilia-associated role, mammalian MIP-T3 localizes to basal bodies and cilia, and zebrafish mipt3 functions synergistically with the Bardet-Biedl syndrome protein Bbs4 to ensure proper gastrulation, a key cilium- and basal body-dependent developmental process. Our findings therefore implicate MIP-T3 in a previously unknown but critical role in cilium biogenesis and further highlight the emerging role of this organelle in vertebrate development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.