ArticlePLoS computational biology2008
Electrotonic signals along intracellular membranes may interconnect dendritic spines and nucleus.
Article in PLoS computational biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Calmodulin controls spatial and temporal specificity of calcium-induced calcium release.PLoS computational biology · 2026Article
- Electrical signals in the ER are cell type and stimulus specific with extreme spatial compartmentalization in neurons.Cell reports · 2023Article
- Distinctive properties of biological neural networks and recent advances in bottom-up approaches toward a better biologically plausible neural network.Frontiers in computational neuroscience · 2023Review
- What Is Required for Neuronal Calcium Waves? A Numerical Parameter Study.Journal of mathematical neuroscience · 2018Article
- Generating Neuron Geometries for Detailed Three-Dimensional Simulations Using AnaMorph.Neuroinformatics · 2017Article
- Solitonic conduction of electrotonic signals in neuronal branchlets with polarized microstructure.Scientific reports · 2017Article
- Induced mitochondrial membrane potential for modeling solitonic conduction of electrotonic signals.PloS one · 2017Article
- Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex.Neuroscience · 2016Article
- Neuronal calcium wave propagation varies with changes in endoplasmic reticulum parameters: a computer model.Neural computation · 2015Article
- Nuclear calcium signalling in the regulation of brain function.Nature reviews. Neuroscience · 2013Review
- Efficient calculation of the quasi-static electrical potential on a tetrahedral mesh and its implementation in STEPS.Frontiers in computational neuroscience · 2013Article
- Membrane "potential-omics": toward voltage imaging at the cell population level in roots of living plants.Frontiers in plant science · 2013Article
- Calcium signaling in synapse-to-nucleus communication.Cold Spring Harbor perspectives in biology · 2011Review
- Ion channels at the nucleus: electrophysiology meets the genome.Molecular plant · 2010Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synapses on dendritic spines of pyramidal neurons show a remarkable ability to induce phosphorylation of transcription factors at the nuclear level with a short latency, incompatible with a diffusion process from the dendritic spines to the nucleus. To account for these findings, we formulated a novel extension of the classical cable theory by considering the fact that the endoplasmic reticulum (ER) is an effective charge separator, forming an intrinsic compartment that extends from the spine to the nuclear membrane. We use realistic parameters to show that an electrotonic signal may be transmitted along the ER from the dendritic spines to the nucleus. We found that this type of signal transduction can additionally account for the remarkable ability of the cell nucleus to differentiate between depolarizing synaptic signals that originate from the dendritic spines and back-propagating action potentials. This study considers a novel computational role for dendritic spines, and sheds new light on how spines and ER may jointly create an additional level of processing within the single neuron.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.