Evidence map›Paper›PMID 18369404›Full record

ArticleCurrent genomics2006

The e3 ubiquitin ligase gene family in plants: regulation by degradation.

E Mazzucotelli, S Belloni, D Marone, Am De Leonardis, D Guerra, N Di Fonzo, L Cattivelli, Am Mastrangelo

Open access · greenAbstract read
In one paragraph

Article in Current genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 1 synthesis or guideline pooled it, 276 citations in OpenAlex.

  1. Pooled it
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  13. An In Vitro Ubiquitination Assay to Study Phytoplasmal Effector Function.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
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77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

E MazzucotelliC.R.A.-Experimental Institute for Cereal Research, Section of Foggia, S.S. 16 km 675, 71100 Foggia, Italy.
S Belloni
D Marone
Am De Leonardis
D Guerra
N Di Fonzo
L Cattivelli
Am Mastrangelo
Cereal Research Centre · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regulation of protein expression and activity has been for long time considered only in terms of transcription/translation efficiency. In the last years, the discovery of post-transcriptional and post-translational regulation mechanisms pointed out that the key factor in determining transcript/protein amount is the synthesis/degradation ratio, together with post-translational modifications of proteins. Polyubiquitinaytion marks target proteins directed to degradation mediated by 26S-proteasome. Recent functional genomics studies pointed out that about 5% of Arabidopsis genome codes for proteins of ubiquitination pathway. The most of them (more than one thousand genes) correspond to E3 ubiquitin ligases that specifically recognise target proteins. The huge size of this gene family, whose members are involved in regulation of a number of biological processes including hormonal control of vegetative growth, plant reproduction, light response, biotic and abiotic stress tolerance and DNA repair, indicates a major role for protein degradation in control of plant life.

Indexed as

E3 ubiquitin ligaseplantpost-translational regulation

Identifiers

PMID18369404
PMCPMC2269001
OpenAlexW2050994851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.