ArticleEMBO reports2008
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA.
Article in EMBO reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- RBM8A promotes gastric cancer progression by binding with UPF3B to induce BBC3 mRNA degradation.International journal of molecular medicine · 2025Article
- Diverse Roles of the Exon Junction Complex Factors in the Cell Cycle, Cancer, and Neurodevelopmental Disorders-Potential for Therapeutic Targeting.International journal of molecular sciences · 2022Review
- The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration.Cellular and molecular life sciences : CMLS · 2019Review
- Article
- Regulation of gene expression by translation factor eIF5A: Hypusine-modified eIF5A enhances nonsense-mediated mRNA decay in human cells.Translation (Austin, Tex.) · 2017Article
- Quantitative Proteomics Reveals the Roles of Peroxisome-associated Proteins in Antiviral Innate Immune Responses.Molecular & cellular proteomics : MCP · 2015Article
- A post-translational regulatory switch on UPF1 controls targeted mRNA degradation.Genes & development · 2014Article
- Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells.Nature structural & molecular biology · 2013Article
- UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps.Molecular cell · 2010Article
- Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis.Molecular cancer research : MCR · 2010Review
- Gene expression networks: competing mRNA decay pathways in mammalian cells.Biochemical Society transactions · 2009Review
- Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta.Genes & development · 2009Article
- SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs.Genes & development · 2009Article
- The multiple lives of NMD factors: balancing roles in gene and genome regulation.Nature reviews. Genetics · 2008Review
- Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay.Cell · 2008Article
Corrections and comments
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4 authors.
Funding
Abstract
Nonsense-mediated messenger RNA decay (NMD) generally degrades mRNAs that prematurely terminate translation as a means of quality control. NMD in mammalian cells targets newly spliced mRNA that is bound by the cap-binding protein heterodimer CBP80/20 and one or more post-splicing exon junction complexes during a pioneer round of translation. NMD targets mRNA that initiates translation using the encephalomyocarditis virus (EMCV) internal ribosome entry site (IRES), therefore NMD might target not only CBP80/20-bound mRNA but also its remodelled product, eIF4E-bound mRNA. Here, we provide evidence that NMD triggered by translation initiation at the EMCV IRES, similar to NMD triggered by translation initiation at an mRNA cap, targets CBP80/20-bound mRNA but does not detectably target eIF4E-bound mRNA. We show that EMCV IRES-initiated translation undergoes a CBP80/20-associated pioneer round of translation that results in CBP80/20-dependent and Upf factor-dependent NMD when translation terminates prematurely.
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