ArticleThe EMBO journal2008
Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases.
Article in The EMBO journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Critical roles ofLife science alliance · 2025Article
- Differentiation signals from glia are fine-tuned to set neuronal numbers during development.eLife · 2022Article
- Gene regulatory networks during the development of the Drosophila visual system.Current topics in developmental biology · 2020Review
- Regulatory mechanisms of EGFR signalling during Drosophila eye development.Cellular and molecular life sciences : CMLS · 2016Review
- Maintenance of glia in the optic lamina is mediated by EGFR signaling by photoreceptors in adult Drosophila.PLoS genetics · 2015Article
- Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease.Human molecular genetics · 2014Article
- Regulation of receptor tyrosine kinase ligand processing.Cold Spring Harbor perspectives in biology · 2014Article
- Cytoplasmic capes are nuclear envelope intrusions that are enriched in endosomal proteins and depend upon βH-spectrin and Annexin B9.PloS one · 2014Article
- Signaling mechanisms controlling cell fate and embryonic patterning.Cold Spring Harbor perspectives in biology · 2012Review
- Review
- Intracellular trafficking in Drosophila visual system development: a basis for pattern formation through simple mechanisms.Developmental neurobiology · 2011Review
- Golgi during development.Cold Spring Harbor perspectives in biology · 2011Review
- Regulation of developmental intercellular signalling by intracellular trafficking.The EMBO journal · 2011Review
- Article
- Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery.PLoS biology · 2010Article
- Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila.PLoS genetics · 2010Article
- rhomboid mediates specification of blue- and green-sensitive R8 photoreceptor cells in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The role of protease activity in ErbB biology.Experimental cell research · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We explore the role of differential compartmentalization of Rhomboid (Rho) proteases that process the Drosophila EGF receptor ligands, in modulating the amount of secreted ligand and consequently the level of EGF receptor (EGFR) activation. The mSpitz ligand precursor is retained in the ER, and is trafficked by the chaperone Star to a late compartment of the secretory pathway, where Rho-1 resides. This work demonstrates that two other Rho proteins, Rho-2 and Rho-3, which are expressed in the germ line and in the developing eye, respectively, cleave the Spitz precursor and Star already in the ER, in addition to their activity in the late compartment. This property attenuates EGFR activation, primarily by compromising the amount of chaperone that can productively traffic the ligand precursor to the late compartment, where cleavage and subsequent secretion take place. These observations identify changes in intracellular compartment localization of Rho proteins as a basis for signal attenuation, in tissues where EGFR activation must be highly restricted in space and time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.