ReviewRNA (New York, N.Y.)2008
Modulating the activity of the peptidyl transferase center of the ribosome.
Review in RNA (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Mutational Analyses of the Cysteine-Rich Domain of Yvh1, a Protein Required for Translational Competency in Yeast.Biology · 2022Article
- Identification of the amino acids inserted during suppression of CFTR nonsense mutations and determination of their functional consequences.Human molecular genetics · 2017Article
- Expression of distinct maternal and somatic 5.8S, 18S, and 28S rRNA types during zebrafish development.RNA (New York, N.Y.) · 2017Article
- Structure and variation of the mitochondrial genome of fishes.BMC genomics · 2016Article
- Arginine changes the conformation of the arginine attenuator peptide relative to the ribosome tunnel.Journal of molecular biology · 2012Article
- Birth, life and death of nascent polypeptide chains.Biotechnology journal · 2011Review
- The 2'-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC.The EMBO journal · 2011Article
- Non-bulk-like solvent behavior in the ribosome exit tunnel.PLoS computational biology · 2010Article
- Genetic identification of nascent peptides that induce ribosome stalling.The Journal of biological chemistry · 2009Article
- Natural amino acids do not require their native tRNAs for efficient selection by the ribosome.Nature chemical biology · 2009Article
- A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function.Biochimica et biophysica acta · 2009Review
- The ribosome: a metabolite-responsive transcription regulator.Journal of bacteriology · 2008Review
- A structural view on the mechanism of the ribosome-catalyzed peptide bond formation.Biochimica et biophysica actaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The peptidyl transferase (PT) center of the ribosome catalyzes two nucleophilic reactions, peptide bond formation between aminoacylated tRNA substrates and, together with release factor, peptide release. Structure and function of the PT center are modulated by binding of aminoacyl-tRNA or release factor, thus providing the basis for the specificity of catalysis. Another way by which the function of the PT center is controlled is signaling from the peptide exit tunnel. The SecM nascent peptide induces ribosome stalling, presumably by inhibition of peptide bond formation. Similarly, the release factor-induced hydrolytic activity of the PT center can be suppressed by the TnaC nascent peptide contained in the exit tunnel. Thus, local and long-range conformational rearrangements can lead to changes in the reaction specificity and catalytic activity of the PT center.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.