ArticleRNA (New York, N.Y.)2008
The aptamer core of SAM-IV riboswitches mimics the ligand-binding site of SAM-I riboswitches.
Article in RNA (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- A cooperative effect of ligands, MgThe Journal of biological chemistry · 2026Article
- Linking folding dynamics and function of SAM/SAH riboswitches at the single molecule level.Nucleic acids research · 2023Article
- Magnesium ions mediate ligand binding and conformational transition of the SAM/SAH riboswitch.Communications biology · 2023Article
- Magnesium ions mediate ligand binding and conformational transition of the SAM/SAH riboswitch.bioRxiv : the preprint server for biology · 2023Article
- Article
- Architectures and complex functions of tandem riboswitches.RNA biology · 2022Article
- Article
- ComprehensiveMicrobial genomics · 2021Article
- Discovery and characterization of a fourth class of guanidine riboswitches.Nucleic acids research · 2020Article
- Imaginary Ribozymes.ACS chemical biology · 2020Article
- Crystal structure and ligand-induced folding of the SAM/SAH riboswitch.Nucleic acids research · 2020Article
- A novel riboswitch classification based on imbalanced sequences achieved by machine learning.PLoS computational biology · 2020Article
- Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures.Nature methods · 2020Article
- A SAM-I riboswitch with the ability to sense and respond to uncharged initiator tRNA.Nature communications · 2020Article
- Interactions between SAM and the 5' UTR mRNA of theRNA (New York, N.Y.) · 2020Article
- Classification of Riboswitch Families Using Block Location-Based Feature Extraction (BLBFE) Method.Advanced pharmaceutical bulletin · 2020Article
- SAM-VI riboswitch structure and signature for ligand discrimination.Nature communications · 2019Article
- Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution.Nature communications · 2019Article
- Disruption of the OLE ribonucleoprotein complex causes magnesium toxicity in Bacillus halodurans.Molecular microbiology · 2019Article
- Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection.Nature communications · 2019Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
A novel family of riboswitches, called SAM-IV, is the fourth distinct set of mRNA elements to be reported that regulate gene expression via direct sensing of S-adenosylmethionine (SAM or AdoMet). SAM-IV riboswitches share conserved nucleotide positions with the previously described SAM-I riboswitches, despite rearranged structures and nucleotide positions with family-specific nucleotide identities. Sequence analysis and molecular recognition experiments suggest that SAM-I and SAM-IV riboswitches share similar ligand binding sites, but have different scaffolds. Our findings support the view that RNA has considerable structural versatility and reveal that riboswitches exploit this potential to expand the scope of RNA in genetic regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.