ArticleGenome research2008
SNP-specific array-based allele-specific expression analysis.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 68 citations in OpenAlex.
- Identification of candidate causal variants and target genes at 41 breast cancer risk loci through differential allelic expression analysis.Scientific reports · 2024Article
- Allele-Specific Expression of CD4Genes · 2019Article
- Allelic imbalance and haploinsufficiency in MYBPC3-linked hypertrophic cardiomyopathy.Pflugers Archiv : European journal of physiology · 2019Review
- Quantification of allelic differential expression using a simple Fluorescence primer PCR-RFLP-based method.Scientific reports · 2019Article
- Allele-specific expression in a family quartet with autism reveals mono-to-biallelic switch and novel transcriptional processes of autism susceptibility genes.Scientific reports · 2018Article
- Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy.Journal of muscle research and cell motility · 2017Article
- SCALE: modeling allele-specific gene expression by single-cell RNA sequencing.Genome biology · 2017Article
- Maternally expressed NLRP2 links the subcortical maternal complex (SCMC) to fertility, embryogenesis and epigenetic reprogramming.Scientific reports · 2017Article
- Discovering Single Nucleotide Polymorphisms Regulating Human Gene Expression Using Allele Specific Expression from RNA-seq Data.Genetics · 2016Article
- The landscape of genomic imprinting across diverse adult human tissues.Genome research · 2015Article
- A NovelMolecular genetics & genomic medicine · 2013Article
- Assignment of SNP allelic configuration in polyploids using competitive allele-specific PCR: application to citrus triploid progeny.Annals of botany · 2013Article
- Identifying breast cancer risk loci by global differential allele-specific expression (DASE) analysis in mammary epithelial transcriptome.BMC genomics · 2012Article
- Transcriptome-wide survey of mouse CNS-derived cells reveals monoallelic expression within novel gene families.PloS one · 2012Article
- Highly parallel SNP genotyping reveals high-resolution landscape of mono-allelic Ube3a expression associated with locus-wide antisense transcription.Nucleic acids research · 2011Article
- An optimized microarray platform for assaying genomic variation in Plasmodium falciparum field populations.Genome biology · 2011Article
- Deterministic and stochastic allele specific gene expression in single mouse blastomeres.PloS one · 2011Article
- Genome-Wide Identification and Quantification of cis- and trans-Regulated Genes Responding to Marek's Disease Virus Infection via Analysis of Allele-Specific Expression.Frontiers in genetics · 2011Article
- Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.PLoS genetics · 2010Article
- Data analysis issues for allele-specific expression using Illumina's GoldenGate assay.BMC bioinformatics · 2010Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
We have developed an optimized array-based approach for customizable allele-specific gene expression (ASE) analysis. The central features of the approach are the ability to select SNPs at will for detection, and the absence of need to PCR amplify the target. A surprisingly long probe length (39-49 nt) was needed for allelic discrimination. Reconstitution experiments demonstrate linearity of ASE over a broad range. Using this approach, we have discovered at least two novel imprinted genes, NLRP2, which encodes a member of the inflammasome, and OSBPL1A, which encodes a presumed oxysterol-binding protein, were both preferentially expressed from the maternal allele. In contrast, ERAP2, which encodes an aminopeptidase, did not show preferential parent-of-origin expression, but rather, cis-acting nonimprinted differential allelic control. The approach is scalable to the whole genome and can be used for discovery of functional epigenetic modifications in patient samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.