Evidence map›Paper›PMID 18368529›Full record

ArticlePurinergic signalling2008

Purinergic signaling microenvironments: An introduction.

Erik M Schwiebert, J Gregory Fitz

Open access · hybridAbstract read
In one paragraph

Article in Purinergic signalling, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Erik M SchwiebertDepartments of Physiology and Biophysics and Cell Biology, University of Alabama at Birmingham, Birmingham, AL, USA. eschwiebert@physiology.uab.edu.
J Gregory Fitz
The University of Texas Southwestern Medical Center · USUniversity of Alabama at Birmingham · US

Funding

Regulation of Secretion by Bile Duct Epithelial CellsR37DK046082 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI FITZ, JOHN GREGORY · 2002 to 2012
$3.3M
MECHANISMS OF HEPATIC ELECTROLYTE TRANSPORTR01DK043278 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI FITZ, JOHN GREGORY · 1991 to 2007
$2.3M
Ion Transport Dysregulation in Cilium-deficient ARPKDR01DK067343 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BEVENSEE, MARK OLIVER · 2005 to 2009
$1.3M
EXTRACELLAR NUCLEOTIDE SIGNALING IN CYSTIC FIBROSISR01DK054367 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHWIEBERT, ERIK MILLS · 2000 to 2004
$856k
EPITHELIAL P2X PURINERGIC RECEPTOR CHANNELSR01HL063934 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHWIEBERT, ERIK MILLS · 2000 to 2003
$799k
NHLBI NIH HHS R01 HL063934NIDDK NIH HHS R01 DK043278NIDDK NIH HHS R01 DK054367NIDDK NIH HHS R01 DK067343NIDDK NIH HHS R37 DK046082
6 · The paper itself

Abstract

The common theme of this introductory article and the minireviews that follow in this special issue is the concept of microenvironments within tissues and surrounding cells that would be ideal signaling venues for a biologically active purinergic ligand. Collectively, the editors/authors and the other contributing authors agree that nucleotides and nucleosides would be most potent within a confined system. A talented cadre of purinergics has been solicited to discuss purinergic signaling in his or her favorite microenvironment within a given organ or tissue. We are gratified by the large number of original articles that also have successfully navigated the peer review process and are part of this special issue. These concepts are not simply purinergic, but the idea of maximal potency in a tissue microenvironment and surrounding specialized cells within a tissue pertains to any autacoid or paracrine agonist.

Identifiers

PMID18368529
PMCPMC2377319
OpenAlexW1969962976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.