ArticleDigestive diseases and sciences2008
Mannan-binding lectin (MBL) polymorphism and gastric cancer risk in Japanese population.
Article in Digestive diseases and sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Innate IgM antibodies to mannose in patients with gastric cancer.Cancer biology & medicine · 2023Article
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- Review
- Mannan-Binding Lectin Deficiency Limits Inflammation-induced Myeloid-Derived Suppressor Cells Expansion via Modulating Tumor Necrosis Factor Alpha-triggered Apoptosis.International journal of biological sciences · 2022Article
- Article
- Clinical significance of mannose-binding lectin expression in thyroid carcinoma tissues.Pathology oncology research : POR · 2013Article
- Mannose-binding lectin 2 gene and risk of adult glioma.PloS one · 2013Article
- 3'-UTR and functional secretor haplotypes in mannose-binding lectin 2 are associated with increased colon cancer risk in African Americans.Cancer research · 2012Article
- Genetic Polymorphisms of Molecules Associated with Innate Immune Responses, TRL2 and MBL2 Genes in Japanese Subjects with Functional Dyspepsia.Journal of clinical biochemistry and nutrition · 2010Article
- Role of bacteria in oncogenesis.Clinical microbiology reviews · 2010Review
- Proteomics analysis of serum protein profiling in pancreatic cancer patients by DIGE: up-regulation of mannose-binding lectin 2 and myosin light chain kinase 2.BMC gastroenterology · 2010Article
- Polymorphisms of the mannan-binding lectin gene and systemic malignancies.Digestive diseases and sciences · 2008Article
- MiR-942-3p Promotes the Proliferation and Invasion of Hepatocellular Carcinoma Cells by Targeting MBL2.Cancer control : journal of the Moffitt Cancer CenterArticle
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19 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMannan-binding lectin (MBL) is believed to be an important constituent of the innate immune system. It has been reported that the codon 54 G/A polymorphism of exon-1 affects the MBL2 gene and alters its activity.
aimsWe investigated the association between polymorphism of the MBL2 gene and gastric cancer risk as well as Helicobacter pylori infection in a Japanese population.
methodsThe study cohort comprised 388 gastric cancer patients and 144 healthy volunteers. Polymorphism at codon 54 of exon 1 of the MBL2 gene was investigated by PCR-based restriction fragment length polymorphism analysis.
resultsThere was no significant difference in the distribution of the MBL2 genotype among the gastric cancer patients and healthy controls. However, the carrier of the A allele was more prevalent among patients with a more advanced stage gastric cancer [odds ratio (OR) 1.68, 95% confidence interval (CI) 1.05-2.67; P = 0.03] and also had an increased risk of gastric cancer among patients 65 years of age or younger (OR = 1.6, 95%CI = 1.01-2.52, <0.05).
conclusionThe codon 54 polymorphism of the MBL2 gene is associated with more advanced phenotypes of gastric cancer and the risk of gastric cancer in Japanese patients 65 years of age or younger.
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