Role of SHP2 for FLT3-dependent proliferation and transformation in 32D cells.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

12 citing papers in PubMed.

1. Targeting MCL-1 and MAPK overcomes venetoclax resistance in FLT3-ITD-positive AML cells harbouring activating PTPN11 (SHP-2) mutations.British journal of haematology · 2026
   Article
2. Targeting Oncogenic Activity and Signalling of Mutant Receptor Tyrosine Kinase FLT3.Cancers · 2025
   Review
3. Disrupting PTPRJ transmembrane-mediated oligomerization counteracts oncogenic receptor tyrosine kinase FLT3 ITD.Frontiers in oncology · 2022
   Article
4. Novel Approaches to Target Mutant FLT3 Leukaemia.Cancers · 2020
   Review
5. Wild-type FLT3 and FLT3 ITD exhibit similar ligand-induced internalization characteristics.Journal of cellular and molecular medicine · 2020
   Article
6. Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma.Haematologica · 2014
   Article
7. A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling.Leukemia · 2013
   Article
8. The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.Leukemia · 2013
   Article
9. Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.Cell communication and signaling : CCS · 2012
   Article
10. Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.The Journal of biological chemistry · 2011
    Article
11. FES kinases are required for oncogenic FLT3 signaling.Leukemia · 2010
    Article
12. SHP-2 tyrosine phosphatase in human diseases.International journal of clinical and experimental medicine · 2009
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

6 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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