ArticleDevelopment (Cambridge, England)2008
Cell type specificity of a diffusible inducer is determined by a GATA family transcription factor.
Article in Development (Cambridge, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Transcriptomics informed discovery of developmentally essential transcription factors.Biology open · 2025Article
- Atypical MAP kinases - new insights and directions from amoeba.Journal of cell science · 2023Review
- An atypical MAPK regulates translocation of a GATA transcription factor in response to chemoattractant stimulation.Journal of cell science · 2022Article
- The genetic architecture underlying prey-dependent performance in a microbial predator.Nature communications · 2022Article
- Coordination between patterning and morphogenesis ensures robustness during mouse development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Cell Cycle Heterogeneity Can Generate Robust Cell Type Proportioning.Developmental cell · 2018Article
- Cell-type specific RNA-Seq reveals novel roles and regulatory programs for terminally differentiated Dictyostelium cells.BMC genomics · 2018Article
- Evidence that differentiation-inducing factor-1 controls chemotaxis and cell differentiation, at least in part, via mitochondria inBiology open · 2017Article
- The GATA transcription factor gene gtaG is required for terminal differentiation in Dictyostelium.Journal of cell science · 2016Article
- Secreted Cyclic Di-GMP Induces Stalk Cell Differentiation in the Eukaryote Dictyostelium discoideum.Journal of bacteriology · 2016Review
- The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium.Nature communications · 2015Article
- Genetic control of morphogenesis in Dictyostelium.Developmental biology · 2015Review
- The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes.Molecular biology of the cell · 2015Article
- Cell signaling during development of Dictyostelium.Developmental biology · 2014Review
- Article
- An orthologue of the Myelin-gene Regulatory Transcription Factor regulates Dictyostelium prestalk differentiation.The International journal of developmental biology · 2012Article
- DIF-1 regulates Dictyostelium basal disc differentiation by inducing the nuclear accumulation of a bZIP transcription factor.Developmental biology · 2011Article
- A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation.Developmental biology · 2011Article
- Cell type-specific filamin complex regulation by a novel class of HECT ubiquitin ligase is required for normal cell motility and patterning.Development (Cambridge, England) · 2011Article
- Dictyostelium finds new roles to model.Genetics · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
One poorly understood mechanism of developmental patterning involves the intermingled differentiation of different cell types that then sort out to generate pattern. Examples of this are known in nematodes and vertebrates, and in Dictyostelium it is the major mechanism. However, a general problem with this mechanism is the possibility that different inducers are required for each cell type that arises independently of positional information. Consistent with this idea, in Dictyostelium the signalling molecule DIF acts as a position-independent signal and was thought only to regulate the differentiation of a single cell type (pstO). The results presented here challenge this idea. In a novel genetic selection to isolate genes required for DIF signal transduction, we found a mutant (dimC(-)) that is a hypomorphic allele of a GATA family transcription factor (gtaC). gtaC expression is directly regulated by DIF, and GtaC rapidly translocates to the nucleus in response to DIF. gtaC(-) null cells showed some hallmark DIF signalling defects. Surprisingly, other aspects of the mutant were distinct from those of other DIF signalling mutants, suggesting that gtaC regulates a subset of DIF responses. For example, pstO cell differentiation appeared normal. However, we found that pstB cells were mislocalised and the pstB-derived basal disc was much reduced or missing. These defects are due to a failure to respond to DIF as they are phenocopied in other DIF signalling mutants. These findings therefore identify a novel small-molecule-activated GATA factor that is required to regulate the cell type-specific effects of DIF. They also reveal that a non-positional signal can regulate the differentiation of multiple cell types through differential interpretation in receiving cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.