ArticleMolecular biology of the cell2008
The signaling adaptor protein CD3zeta is a negative regulator of dendrite development in young neurons.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
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- An opinion on the debatable function of brain resident immune protein, T-cell receptor beta subunit in the central nervous system.IBRO neuroscience reports · 2022Article
- T Cell Reprogramming Against Cancer.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Role of the Immune System in the Development of the Central Nervous System.Frontiers in neuroscience · 2019Review
- The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs.American journal of human genetics · 2017Article
- CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- The Major Histocompatibility Complex (MHC) in Schizophrenia: A Review.Journal of clinical & cellular immunology · 2016Article
- Major histocompatibility complex I in brain development and schizophrenia.Biological psychiatry · 2014Review
- From mechanosensitivity to inflammatory responses: new players in the pathology of glaucoma.Current eye research · 2014Review
- T-cell receptor activation decreases excitability of cortical interneurons by inhibiting α7 nicotinic receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Impaired spatial memory in mice lacking CD3ζ is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Slow angled-descent forepaw grasping (SLAG): an innate behavioral task for identification of individual experimental mice possessing functional vision.Behavioral and brain functions : BBF · 2013Article
- Major histocompatibility complex class I proteins in brain development and plasticity.Trends in neurosciences · 2012Review
- Ectopic expression of the immune adaptor protein CD3zeta in neural stem/progenitor cells disrupts cell-fate specification.Journal of molecular neuroscience : MN · 2012Article
- Exacerbation of experimental autoimmune encephalomyelitis in prion protein (PrPc)-null mice: evidence for a critical role of the central nervous system.Journal of neuroinflammation · 2012Article
- Astrocytic αVβ3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1.PloS one · 2012Article
- Developmental mechanisms that regulate retinal ganglion cell dendritic morphology.Developmental neurobiology · 2011Article
- CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel idea is emergxsing that a large molecular repertoire is common to the nervous and immune systems, which might reflect the existence of novel neuronal functions for immune molecules in the brain. Here, we show that the transmembrane adaptor signaling protein CD3zeta, first described in the immune system, has a previously uncharacterized role in regulating neuronal development. Biochemical and immunohistochemical analyses of the rat brain and cultured neurons showed that CD3zeta is mainly expressed in neurons. Distribution of CD3zeta in developing cultured hippocampal neurons, as determined by immunofluorescence, indicates that CD3zeta is preferentially associated with the somatodendritic compartment as soon as the dendrites initiate their differentiation. At this stage, CD3zeta was selectively concentrated at dendritic filopodia and growth cones, actin-rich structures involved in neurite growth and patterning. siRNA-mediated knockdown of CD3zeta in cultured neurons or overexpression of a loss-of-function CD3zeta mutant lacking the tyrosine phosphorylation sites in the immunoreceptor tyrosine-based activation motifs (ITAMs) increased dendritic arborization. Conversely, activation of endogenous CD3zeta by a CD3zeta antibody reduced the size of the dendritic arbor. Altogether, our findings reveal a novel role for CD3zeta in the nervous system, suggesting its contribution to dendrite development through ITAM-based mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.