ArticleMolecular biology and evolution2008
Retrotransposition as a source of new promoters.
Article in Molecular biology and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Retrotransposition Events Shape the Evolution of the Ataxin-3 Gene Family in Primates.Genome biology and evolution · 2026Article
- From Genomic Fossils to Functional Elements: The Evolving Story of Pseudogenes.Advanced genetics (Hoboken, N.J.) · 2025Review
- Evolution of retrocopies in the context of HUSH silencing.Biology direct · 2024Article
- Pseudogenes in Cancer: State of the Art.Cancers · 2023Review
- Retrotransposition facilitated the establishment of a primary plastid in the thecate amoebaProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Diversification of CpG-Island Promoters Revealed by Comparative Analysis Between Human and Rhesus Monkey Genomes.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Article
- Frequent retrotransposition of endogenous genes in ERCC2-deficient cells derived from a patient with xeroderma pigmentosum.Stem cell research & therapy · 2019Article
- Translocation of promoter-conserved hatching enzyme genes with intron-loss provides a new insight in the role of retrocopy during teleostean evolution.Scientific reports · 2019Article
- Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Review
- Evolutionary fates of universal stress protein paralogs in Platyhelminthes.BMC evolutionary biology · 2018Article
- Protein-Coding Genes' Retrocopies and Their Functions.Viruses · 2017Review
- Identification of Multiple Forms of RNA Transcripts Associated with Human-Specific Retrotransposed Gene Copies.Genome biology and evolution · 2016Article
- Correlated expression of retrocopies and parental genes in zebrafish.Molecular genetics and genomics : MGG · 2016Article
- The life history of retrocopies illuminates the evolution of new mammalian genes.Genome research · 2016Article
- Novel Role of 3'UTR-Embedded Alu Elements as Facilitators of Processed Pseudogene Genesis and Host Gene Capture by Viral Genomes.PloS one · 2016Article
- How evolution of genomes is reflected in exact DNA sequence match statistics.Molecular biology and evolution · 2015Article
- Evolution of Vertebrate Adam Genes; Duplication of Testicular Adams from Ancient Adam9/9-like Loci.PloS one · 2015Article
- Pollen-specific activation of Arabidopsis retrogenes is associated with global transcriptional reprogramming.The Plant cell · 2014Article
- Early disruption of maternal-zygotic interaction and activation of defense-like responses in Arabidopsis interspecific crosses.The Plant cell · 2013Article
- Gene copy-number polymorphism caused by retrotransposition in humans.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fact that promoters are essential for the function of all genes presents the basis of the general idea that retrotranspositions give rise to processed pseudogenes. However, recent studies have demonstrated that some retrotransposed genes are transcriptionally active. Because promoters are not thought to be retrotransposed along with exonic sequences, these transcriptionally active genes must have acquired a functional promoter by mechanisms that are yet to be determined. Hence, comparison between a retrotransposed gene and its source gene appears to provide a unique opportunity to investigate the promoter creation for a new gene. Here, we identified 29 gene pairs in the human genome, consisting of a functional retrotransposed gene and its parental gene, and compared their respective promoters. In more than half of these cases, we unexpectedly found that a large part of the core promoter had been transcribed, reverse transcribed, and then integrated to be operative at the transposed locus. This observation can be ascribed to the recent discovery that transcription start sites tend to be interspersed rather than situated at 1 specific site. This propensity could confer retrotransposability to promoters per se. Accordingly, the retrotransposability can explain the genesis of some alternative promoters.
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