ArticleNeurobiology of aging2009
Action potential throughput in aged rat hippocampal neurons: regulation by selective forms of hyperpolarization.
Article in Neurobiology of aging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- A biophysical minimal model to investigate age-related changes in CA1 pyramidal cell electrical activity.PloS one · 2024Article
- Age-related deficits in neuronal physiology and cognitive function are recapitulated in young mice overexpressing the L-type calcium channel, CaAging cell · 2023Article
- Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters.Neurobiology of aging · 2020Article
- Electrophysiological and Imaging Calcium Biomarkers of Aging in Male and Female 5×FAD Mice.Journal of Alzheimer's disease : JAD · 2020Article
- Senescent neurophysiology: CaNeurobiology of learning and memory · 2019Review
- Early functional alterations in membrane properties and neuronal degeneration are hallmarks of progressive hearing loss in NOD mice.Scientific reports · 2019Article
- Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Novel calcium-related targets of insulin in hippocampal neurons.Neuroscience · 2017Article
- Calcium's role as nuanced modulator of cellular physiology in the brain.Biochemical and biophysical research communications · 2017Review
- CA1 pyramidal cells have diverse biophysical properties, affected by development, experience, and aging.PeerJ · 2017Article
- Intrinsic Hippocampal Excitability Changes of Opposite Signs and Different Origins in CA1 and CA3 Pyramidal Neurons Underlie Aging-Related Cognitive Deficits.Frontiers in systems neuroscience · 2016Review
- The impact of hippocampal lesions on trace-eyeblink conditioning and forebrain-cerebellar interactions.Behavioral neuroscience · 2015Review
- Characterization of age-related changes in synaptic transmission onto F344 rat basal forebrain cholinergic neurons using a reduced synaptic preparation.Journal of neurophysiology · 2014Article
- Hippocampal calcium dysregulation at the nexus of diabetes and brain aging.European journal of pharmacology · 2013Review
- Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology.Neurobiology of aging · 2012Article
- Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2012Article
- Of mice and intrinsic excitability: genetic background affects the size of the postburst afterhyperpolarization in CA1 pyramidal neurons.Journal of neurophysiology · 2011Article
- GABAergic signaling increases through the postnatal development to provide the potent inhibitory capability for the maturing demands of the prefrontal cortex.Cellular and molecular neurobiology · 2010Article
- Effects of long-term pioglitazone treatment on peripheral and central markers of aging.PloS one · 2010Article
- Cellular mechanisms for altered learning in aging.Future neurology · 2010Article
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2 authors.
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Abstract
At hippocampal synapses, repetitive synaptic stimulation (RSS) in the theta frequency range (3-12Hz) is associated with robust EPSP frequency facilitation (FF) and consequently, enhanced action potential (spike) generation and throughput. A complex, synaptically induced hyperpolarization (SIHP) is also triggered by synaptic activation, and a Ca(2+)-dependent afterhyperpolarization (AHP) is triggered above spike threshold. With aging, the AHP is increased and impairs intracellular spike generation, at least in accommodation protocols. However, little is known about how these aging changes interact to affect spike generation at physiological frequencies of RSS, or if the SIHP also is modified in aging. Here we performed the first tests of the net impact of these excitatory and inhibitory aging changes on spike generation during RSS. We report that during RSS at spike threshold (1) spike throughput is well sustained at theta frequencies in young and aged neurons; (2) an interposed AHP dampens spike generation, particularly in aged neurons and at higher frequencies; (3) compared to the AHP, the SIHP does not exert an equivalent inhibitory effect on spike throughput; and (4) in contrast to the AHP, the SIHP is reduced with aging. Together, these results are consistent with a model in which the source of the hyperpolarization is important in determining hippocampal spike throughput within the theta frequency range.
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