ArticleBMC infectious diseases2008
Serum procalcitonin elevation in critically ill patients at the onset of bacteremia caused by either Gram negative or Gram positive bacteria.
Article in BMC infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- Diagnostic Accuracy of Procalcitonin Compared to C-Reactive Protein and Interleukin 6 in Recognizing Gram-Negative Bloodstream Infection: A Meta-Analytic Study.Disease markers · 2020Pooled it
- Serum procalcitonin as a diagnostic marker for neonatal sepsis: a systematic review and meta-analysis.Intensive care medicine · 2011Pooled it
- Influence of pathogen and focus of infection on procalcitonin values in sepsis patients with bacteremia or candidemia.Critical care (London, England) · 2018Trial
- High procalcitonin in Gram-negative urosepsis: indicator of immune modulation rather than poor outcome.World journal of urology · 2026Article
- Article
- An analysis of lactate/albumin, procalcitonin/albumin, and blood urea nitrogen/albumin ratios as a predictor of mortality in uroseptic patients.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Combination of C-reactive protein, procalcitonin, IL-6, IL-8, and IL-10 for early diagnosis of hyperinflammatory state and organ dysfunction in pediatric sepsis.Journal of clinical laboratory analysis · 2022Article
- T cell activation profiles can distinguish gram negative/positive bacterial sepsis and are associated with ICU discharge.Frontiers in immunology · 2022Observational
- Evaluation of vitreous Procalcitonin as a diagnostic biomarker in infectious endophthalmitis.International ophthalmology · 2021Article
- The Urosepsis-A Literature Review.Medicina (Kaunas, Lithuania) · 2021Review
- Prognostic Value of Procalcitonin and C-Reactive Protein in 1608 Critically Ill Patients with Severe Influenza Pneumonia.Antibiotics (Basel, Switzerland) · 2021Article
- CRP/albumin ratio: A promising marker of gram-negative bacteremia in late-onset neonatal sepsis.Turkish archives of pediatrics · 2021Article
- Challenges and countermeasures of thoracic oncology in the epidemic of COVID-19.Translational lung cancer research · 2020Review
- Serum procalcitonin as a biomarker of bloodstream infection & focal bacterial infection in febrile patients.The Indian journal of medical research · 2020Article
- Procalcitonin as a Predictive Marker for Bacteremia in Children With a Central Line and Fever.Hospital pediatrics · 2019Article
- Procalcitonin-guided antibiotic discontinuation in ventilator-associated pneumonia: a prospective observational study.Infection and drug resistance · 2019Article
- Clinical Characteristics And Risk Factors In Mixed-Enterococcal Bloodstream Infections.Infection and drug resistance · 2019Article
- The Role of Procalcitonin in the Diagnosis of Meningitis: A Literature Review.Journal of clinical medicine · 2018Review
- Diagnostic Accuracy of Procalcitonin for Differentiating Bacteraemic Gram-Negative Sepsis from Gram-Positive Sepsis.Turkish journal of anaesthesiology and reanimation · 2018Article
- Clinical value of procalcitonin for suspected nosocomial bloodstream infection.The Korean journal of internal medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the ICU, bacteremia is a life-threatening infection whose prognosis is highly dependent on early recognition and treatment with appropriate antibiotics. Procalcitonin levels have been shown to distinguish between bacteremia and noninfectious inflammatory states accurately and quickly in critically ill patients. However, we still do not know to what extent the magnitude of PCT elevation at the onset of bacteremia varies according to the Gram stain result.
methodsReview of the medical records of every patient treated between May, 2004 and December, 2006 who had bacteremia caused by either Gram positive (GP) or Gram negative (GN) bacteria, and whose PCT dosage at the onset of infection was available.
results97 episodes of either GN bacteremia (n = 52) or GP bacteremia (n = 45) were included. Procalcitonin levels were found to be markedly higher in patients with GN bacteremia than in those with GP bacteremia, whereas the SOFA score value in the two groups was similar. Moreover, in the study population, a high PCT value was found to be independently associated with GN bacteremia. A PCT level of 16.0 ng/mL yielded an 83.0% positive predictive value and a 74.0% negative predictive value for GN-related bacteremia in the study cohort (AUROCC = 0.79; 95% CI, 0.71-0.88).
conclusionIn a critically ill patient with clinical sepsis, GN bacteremia could be associated with higher PCT values than those found in GP bacteremia, regardless of the severity of the disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.