ArticleBMC physiology2008
Testosterone influences renal electrolyte excretion in SHR/y and WKY males.
Article in BMC physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Sex differences in potassium regulation: evidence, molecular mechanisms and clinical implications.Biology of sex differences · 2026Review
- Short-term effects of orchiectomy on the health condition and renal handling of electrolytes in sexually intact adult male cats.Open veterinary journal · 2025Article
- Integrated renal and sympathetic mechanisms underlying the development of sex- and age-dependent hypertension and the salt sensitivity of blood pressure.GeroScience · 2024Article
- Sex-Specific Differences in Kidney Function and Blood Pressure Regulation.International journal of molecular sciences · 2024Review
- Article
- Selective deletion of endothelial mineralocorticoid receptor protects from vascular dysfunction in sodium-restricted female mice.Biology of sex differences · 2020Article
- Hormonal control of vas deferens fluid volume and aquaporin expression in rats.Journal of molecular histology · 2019Article
- Sex-specific computational models of the spontaneously hypertensive rat kidneys: factors affecting nitric oxide bioavailability.American journal of physiology. Renal physiology · 2017Article
- Selection of suitable endogenous reference genes for qPCR in kidney and hypothalamus of rats under testosterone influence.PloS one · 2017Article
- Regional differences in sexually dimorphic protein expression in the spontaneously hypertensive rat (SHR).Molecular and cellular biochemistry · 2012Article
- Alterations in vasomotor systems and mechanics of resistance-sized mesenteric arteries from SHR and WKY male rats following in vivo testosterone manipulation.Biology of sex differences · 2012Article
- Blood pressure and mesenteric vascular reactivity in spontaneously hypertensive rats 7 months after gonadectomy.Journal of cardiovascular pharmacology · 2011Article
- Testosterone increases: sodium reabsorption, blood pressure, and renal pathology in female spontaneously hypertensive rats on a high sodium diet.Advances in pharmacological sciences · 2011Article
- Involvement of protein kinase C-CPI-17 in androgen modulation of angiotensin II-renal vasoconstriction.Cardiovascular research · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe Y-chromosome (Yc) and testosterone (T) increase blood pressure and may also influence renal electrolyte excretion. Therefore, the goal of this study was to determine if the Yc combined with T manipulation could influence renal Na and K excretion.
methodsTo investigate the role of the Yc and T, consomic borderline hypertensive (SHR/y) and normotensive Wistar-Kyoto (WKY) rat strains were used (15 weeks) in three T treatment groups: castrate, castrate with T implant and gonadally intact males. Urine was collected (24 hrs at 15 weeks of age) for Na and K measurements by flame photometry. RT-PCR was used to demonstrate the presence of renal androgen receptor (AR) transcripts. Plasma T and aldosterone were measured by RIA. In another experiment the androgen receptor was blocked using flutamide in the diet.
resultsNa and K excretion were decreased by T in SHR/y and WKY. AR transcripts were identified in SHR/y and WKY kidneys. Plasma aldosterone was decreased in the presence of T. Blockade of the AR resulted in a significant increase in Na excretion but not in K excretion in both SHR/y and WKY males.
conclusionT influences electrolyte excretion through an androgen receptor dependent mechanism. There was not a differential Yc involvement in electrolyte excretion between WKY and SHR/y males.
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