ArticleBMC genomics2008
Identification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Ethanol exposed maturing rat cerebellar granule cells show impaired energy metabolism and increased cell death after oxygen-glucose deprivation.Neural regeneration research · 2019Article
- Detecting NScientific reports · 2017Article
- Fetal alcohol spectrum disorder: molecular insights into neural damage reduction.Neural regeneration research · 2015Article
- Understanding Transcription Factor Regulation by Integrating Gene Expression and DNase I Hypersensitive Sites.BioMed research international · 2015Article
- Long-term effects of peripubertal binge EtOH exposure on hippocampal microRNA expression in the rat.PloS one · 2014Article
- Transcriptional regulation prediction of antiestrogen resistance in breast cancer based on RNA polymerase II binding data.BMC bioinformatics · 2014Article
- Fetal Alcohol Spectrum Disorder (FASD) Associated Neural Defects: Complex Mechanisms and Potential Therapeutic Targets.Brain sciences · 2013Article
- Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure.Journal of neurodevelopmental disorders · 2013Article
- Multiplexed digital quantification of binge-like alcohol-mediated alterations in maternal uterine angiogenic mRNA transcriptome.Physiological genomics · 2012Article
- The effect of preconception paternal alcohol exposure on epigenetic remodeling of the h19 and rasgrf1 imprinting control regions in mouse offspring.Frontiers in genetics · 2012Article
- Regulatory mechanisms in bone following mechanical loading.Gene regulation and systems biology · 2012Article
- Different sequence signatures in the upstream regions of plant and animal tRNA genes shape distinct modes of regulation.Nucleic acids research · 2011Article
- Integrative analysis of next generation sequencing for small non-coding RNAs and transcriptional regulation in Myelodysplastic Syndromes.BMC medical genomics · 2011Article
- Combinatorial regulation of transcription factors and microRNAs.BMC systems biology · 2010Article
- Genetic and epigenetic insights into fetal alcohol spectrum disorders.Genome medicine · 2010Article
- Genomics, molecular imaging, bioinformatics, and bio-nano-info integration are synergistic components of translational medicine and personalized healthcare research.BMC genomics · 2008Article
- Promoting synergistic research and education in genomics and bioinformatics.BMC genomics · 2008Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
This is a first report, using our MotifModeler informatics program, to simultaneously identify transcription factor (TF) and microRNA (miRNA) binding sites from gene expression microarray data. Based on the assumption that gene expression is controlled by combinatorial effects of transcription factors binding in the 5'-upstream regulatory region and miRNAs binding in the 3'-untranslated region (3'-UTR), we developed a model for (1) predicting the most influential cis-acting elements under a given biological condition, and (2) estimating the effects of those elements on gene expression levels. The regulatory regions, TF and miRNA, which mediate the differential genes expression in fetal alcohol syndrome were unknown; microarray data from alcohol exposure paradigm was used. The model predicted strong inhibitory effects of 5' cis-acting elements and stimulatory effects of 3'-UTR under alcohol treatment. Current predictive model derived a key hypothesis for the first time a novel role of miRNAs in gene expression changes associated with abnormal mouse embryo development after alcohol exposure. This suggests that disturbance of miRNA functions may contribute to the alcohol-induced developmental deficiencies.
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Registered trials
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