Trial reportSurgical endoscopy2008
The use of fibrin sealant to prevent major complications following laparoscopic gastric bypass: results of a multicenter, randomized trial.
Trial report in Surgical endoscopy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03733639 (The Use of Fibrin Glue Sealant), which is not on this map. Cited by 37 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of Fibrin Glue Sealant (Tisseel®) as a Reinforcement of Esophagojejunal Anastomoses Will Decrease the Rate of Anastomotic Leak.
Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Novel adjunctive technologies for the prevention of colorectal anastomotic leakage: a systematic review.Techniques in coloproctology · 2026Pooled it
- Efficacy of Fibrin Sealant in Reducing Complication Risk After Bariatric Surgery: a Systematic Review and Meta-analysis.Obesity surgery · 2021Pooled it
- Training programs influence in the learning curve of laparoscopic gastric bypass for morbid obesity: a systematic review.Obesity surgery · 2012Pooled it
- Obesity in adults.BMJ clinical evidence · 2011Pooled it
- Laparoscopic sleeve gastrectomy: efficacy of fibrin sealant in reducing postoperative bleeding. A randomized controlled trial.Updates in surgery · 2014Trial
- Staple-line reinforcement during laparoscopic sleeve gastrectomy using three different techniques: a randomized trial.Surgical endoscopy · 2012Trial
- Protection of intestinal anastomosis with biological glues: an experimental randomized controlled trial.Techniques in coloproctology · 2011Trial
- Article
- The role of tissue adhesives and sealants in colorectal anastomotic healing-a scoping review.International journal of colorectal disease · 2023Article
- New Technologies to Prevent Anastomotic Leak.Clinics in colon and rectal surgery · 2021Review
- Robotic "Double Loop" Roux-en-Y gastric bypass reduces the risk of postoperative internal hernias: a prospective observational study.Surgical endoscopy · 2021Observational
- Bowel anastomosis leakage following endometriosis surgery: an evidence based analysis of risk factors and prevention techniques.Facts, views & vision in ObGyn · 2020Review
- From the Knife to the Endoscope-a History of Bariatric Surgery.Current obesity reports · 2020Review
- Costs Analysis of Fibrin Sealant for Prevention of Anastomotic Leakage in Lower Colorectal Surgery.Risk management and healthcare policy · 2020Article
- The potential effects of Ankaferd blood stopper and fibrin sealent on sleeve gastrectomy staple-line healing: An experimental study.Experimental and therapeutic medicine · 2019Article
- Improving the adhesion, flexibility, and hemostatic efficacy of a sprayable polymer blend surgical sealant by incorporating silica particles.Acta biomaterialia · 2019Article
- The effect of fibrin glue in preventing staple-line leak after sleeve gastrectomy. An experimental study in rats.Acta cirurgica brasileira · 2019Article
- The mesenteric defects in laparoscopic Roux-en-Y gastric bypass: 5 years follow-up of non-closure versus closure using the stapler technique.Surgical endoscopy · 2017Article
- Effects and results of fibrin sealant use in 1000 laparoscopic sleeve gastrectomy cases.Surgical endoscopy · 2017Article
- Emerging Trends in the Etiology, Prevention, and Treatment of Gastrointestinal Anastomotic Leakage.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPublished interim results have shown that fibrin sealant (Tissucol/Tisseel Baxter AG, Vienna, Austria) may be effective in preventing anastomotic leaks and internal hernias following laparoscopic Roux-en-Y gastric bypass (LRYGBP). We report the final results of a multicenter, randomized clinical trial evaluating the use of fibrin sealant in LRYGBP.
methodsBetween January 2004 and December 2005, 340 patients aged 21-65 years with a body mass index (BMI) of 40-59 kg/m(2) undergoing LRYGBP were randomized (1:1) to two treatment groups: fibrin sealant group (applied to gastrojejunal and jejunojejunal anastomoses and over mesenteric openings), and control group (no fibrin sealant; suture of the mesenteric openings). Operative time, early and late complications, reinterventions, time to oral diet initiation, and length of stay were assessed.
resultsOverall, 320 patients were included into the study: 160 in the control group and 160 in the fibrin sealant group. All patients completed follow-up assessments at 6 and 12 months, and 60.9% completed assessments at 24 months. There were no significant differences between groups with respect to demographics, operative time, oral diet initiation, hospital stay, and BMI reduction at 6, 12, and 24 months. The incidence of anastomotic leak was numerically, but not significantly, greater in the control group. The overall reintervention rate for specific early complications (<30 days) was significantly higher in the control group (p = 0.016). No deaths or conversions to open laparotomy occurred.
conclusionThe use of fibrin sealant in laparoscopic RYGBP may be beneficial in reducing the reintervention rate for major perioperative (<30 days) complications. Larger studies are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.