ArticleThe Journal of biological chemistry2008
Peroxisomes as novel players in cell calcium homeostasis.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Peroxisome calcium uptake is dependent on ER-peroxisome membrane contact.Cellular and molecular life sciences : CMLS · 2026Article
- TFEB activation triggers pexophagy for functional adaptation during oxidative stress under calcium deficient-conditions.Cell communication and signaling : CCS · 2024Article
- Live-Cell Imaging of Peroxisomal Calcium Levels and Dynamics.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The evolution of organellar calcium mapping technologies.Cell calcium · 2022Review
- Review
- Calcium in peroxisomes: An essential messenger in an essential cell organelle.Frontiers in cell and developmental biology · 2022Review
- Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells.Life science alliance · 2021Article
- Cellular Aging Characteristics and Their Association with Age-Related Disorders.Antioxidants (Basel, Switzerland) · 2020Review
- Peroxisomal Metabolite and Cofactor Transport in Humans.Frontiers in cell and developmental biology · 2020Review
- Organellar Calcium Handling in the Cellular Reticular Network.Cold Spring Harbor perspectives in biology · 2019Review
- Altered CaBiochimica et biophysica acta. Molecular cell research · 2018Review
- Pharmacological Strategies for Manipulating Plant CaInternational journal of molecular sciences · 2018Review
- Delivery of Proapoptotic Agents in Glioma Cell Lines by TSPO Ligand-Dextran Nanogels.International journal of molecular sciences · 2018Article
- Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson's Disease and Synucleinopathies.Frontiers in neuroscience · 2018Review
- Exploring cells with targeted biosensors.The Journal of general physiology · 2017Review
- Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes.Nature protocols · 2013Article
- Import of proteins into the peroxisomal matrix.Frontiers in physiology · 2013Review
- Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer's disease.Molecular neurodegeneration · 2013Article
- The peroxisome: an update on mysteries.Histochemistry and cell biology · 2012Review
- Intracellular organelles in the saga of Ca2+ homeostasis: different molecules for different purposes?Cellular and molecular life sciences : CMLS · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Ca2+ concentration in peroxisomal matrix ([Ca2+](perox)) has been monitored dynamically in mammalian cells expressing variants of Ca2+-sensitive aequorin specifically targeted to peroxisomes. Upon stimulation with agonists that induce Ca2+ release from intracellular stores, peroxisomes transiently take up Ca2+ reaching peak values in the lumen as high as 50-100 microm, depending on cell types. Also in resting cells, peroxisomes sustain a Ca2+ gradient, [Ca2+](perox) being approximately 20-fold higher than [Ca2+] in the cytosol ([Ca2+](cyt)). The properties of Ca2+ traffic across the peroxisomal membrane are different from those reported for other subcellular organelles. The sensitivity of peroxisomal Ca2+ uptake to agents dissipating H+ and Na+ gradients unravels the existence of a complex bioenergetic framework including V-ATPase, Ca2+/H+, and Ca2+/Na+ activities whose components are yet to be identified at a molecular level. The different [Ca2+](perox) of resting and stimulated cells suggest that Ca2+ could play an important role in the regulation of peroxisomal metabolism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.