ArticleGenes, brain, and behavior2008
Predator stress induces behavioral inhibition and amygdala somatostatin receptor 2 gene expression.
Article in Genes, brain, and behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- Central amygdala somatostatin neurons modulate stress-induced sleep-onset insomnia.Communications biology · 2025Article
- Comprehensive Review of Chronic Stress Pathways and the Efficacy of Behavioral Stress Reduction Programs (BSRPs) in Managing Diseases.International journal of environmental research and public health · 2024Review
- Somatostatin signaling modulates binge drinking behavior via the central nucleus of the amygdala.Neuropharmacology · 2023Article
- Predation stress experienced as immature mites extends their lifespan.Biogerontology · 2023Article
- ACh signaling modulates activity of the GABAergic signaling network in the basolateral amygdala and behavior in stress-relevant paradigms.Molecular psychiatry · 2022Article
- Convergent neural correlates of prenatal exposure to air pollution and behavioral phenotypes of risk for internalizing and externalizing problems: Potential biological and cognitive pathways.Neuroscience and biobehavioral reviews · 2022Review
- Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area.Molecular psychiatry · 2022Article
- Role of Basolateral Amygdalar Somatostatin 2 Receptors in a Rat Model of Chronic Anxiety.Neuroscience · 2021Article
- A role for the neuropeptide somatostatin in the neurobiology of behaviors associated with substances abuse and affective disorders.Neuropharmacology · 2020Review
- The predator odor avoidance model of post-traumatic stress disorder in rats.Behavioural pharmacology · 2019Review
- Prolonged Bat Call Exposure Induces a Broad Transcriptional Response in the Male Fall Armyworm (Frontiers in behavioral neuroscience · 2019Article
- Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat.Psychopharmacology · 2018Article
- Decreased Numbers of Somatostatin-Expressing Neurons in the Amygdala of Subjects With Bipolar Disorder or Schizophrenia: Relationship to Circadian Rhythms.Biological psychiatry · 2017Article
- Activation of Brain Somatostatin Signaling Suppresses CRF Receptor-Mediated Stress Response.Frontiers in neuroscience · 2017Review
- Chronic mild stress alters the somatostatin receptors in the rat brain.Psychopharmacology · 2016Article
- Oxidant/antioxidant effects of chronic exposure to predator odor in prefrontal cortex, amygdala, and hypothalamus.Molecular and cellular biochemistry · 2015Article
- The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior.Hormones and behavior · 2015Review
- Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?Frontiers in pharmacology · 2013Review
- Modulation of the adaptive response to stress by brain activation of selective somatostatin receptor subtypes.Peptides · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Psychological stressors precipitate and maintain stress-induced psychopathology, and it is likely that altered amygdala function underlies some of the deleterious effects of psychological stress. To understand the mechanisms underlying the linkage between the response to psychological stressors and maladaptive or psychopathological responses, we have focused on amygdala responsivity in animal models employing species-specific psychological stressors. In the present study, we characterized the effects of a 15-min exposure to a natural predator, the ferret, on rat behavior and the expression of the somatostatin family of genes in the amygdala. We examined the somatostatin family of genes because substantial evidence shows that central somatostatin systems are altered in various neuropsychiatric illnesses. We report that rats respond to acute ferret exposure with a significant increase in fearful and anxious behaviors that is accompanied by robust amygdala activation and an increase in somatostatin receptor 2 (sst2) messenger RNA expression within the amygdala and anterior cingulate cortex. These studies are the first to show stress-induced changes in amygdala sst2 expression and may represent one mechanism by which psychological stress is linked to adaptive and maladaptive behavioral responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.