ArticleGenes, brain, and behavior2008
Calcium taste preferences: genetic analysis and genome screen of C57BL/6J x PWK/PhJ hybrid mice.
Article in Genes, brain, and behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Developing and regenerating a sense of taste.Current topics in developmental biology · 2015Review
- Heightened avidity for trisodium pyrophosphate in mice lacking Tas1r3.Chemical senses · 2015Article
- Taste dysfunction in BTBR mice due to a mutation of Itpr3, the inositol triphosphate receptor 3 gene.Physiological genomics · 2013Article
- T1R3: a human calcium taste receptor.Scientific reports · 2012Article
- Accumulating evidence supports a taste component for free fatty acids in humans.Physiology & behavior · 2011Review
- Comparison of differences between PWD/PhJ and C57BL/6J mice in calcium solution preferences and chorda tympani nerve responses.Physiology & behavior · 2011Article
- Taste solution consumption by FHH-Chr nBN consomic rats.Chemical senses · 2010Article
- Involvement of the calcium-sensing receptor in human taste perception.The Journal of biological chemistry · 2010Article
- Genetics of taste and smell: poisons and pleasures.Progress in molecular biology and translational science · 2010Review
- Vegetable bitterness is related to calcium content.Appetite · 2009Article
- Involvement of T1R3 in calcium-magnesium taste.Physiological genomics · 2008Article
- Gene discovery and the genetic basis of calcium consumption.Physiology & behavior · 2008Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
To characterize the genetic basis of voluntary calcium consumption, we tested C57BL/6J mice (B6; with low avidity for calcium), PWK/PhJ mice (PWK; with high avidity for calcium) and their F(1) and F(2) hybrids. All mice received a series of 96-h two-bottle preference tests with a choice between water and the following: 50 mm CaCl(2), 50 mm calcium lactate, 50 mm MgCl(2), 100 mm KCl, 100 mm NH(4)Cl, 100 mm NaCl, 5 mm citric acid, 30 microm quinine hydrochloride and 2 mm saccharin. Most frequency distributions of the parental and F(1) but not F(2) groups were normally distributed, and there were few sex differences. Reciprocal cross analysis showed that B6 x PWK F(1) mice had a non-specific elevation of fluid intake relative to PWK x B6 F(1) mice. In the F(2) mice, trait correlations were clustered among the divalent salts and the monovalent chlorides. A genome screen involving 116 markers showed 30 quantitative trait loci (QTLs), of which six involved consumption of calcium chloride or lactate. The results show pleiotropic controls of calcium and magnesium consumption that are distinct from those controlling consumption of monovalent chlorides or exemplars of the primary taste qualities.
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