ArticleJournal of cellular and molecular medicine2008
The induction of bone formation by smart biphasic hydroxyapatite tricalcium phosphate biomimetic matrices in the non-human primate Papio ursinus.
Article in Journal of cellular and molecular medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 78 citations in OpenAlex.
- Bone Loss around Dental Implants 5 Years after Implantation of Biphasic Calcium Phosphate (HAp/Journal of healthcare engineering · 2018Trial
- Smart biomaterials for cardiovascular, bone, and skin tissue engineering: mechanisms, applications, and future prospects.Journal of biological engineering · 2026Review
- Influence of physicochemical characteristics of calcium phosphate-based biomaterials in cranio-maxillofacial bone regeneration. A systematic literature review and meta-analysis of preclinical models.Materials today. Bio · 2024Article
- Nanohydroxyapatite Electrodeposition onto Electrospun Nanofibers: Technique Overview and Tissue Engineering Applications.Bioengineering (Basel, Switzerland) · 2021Review
- Case Report: Histological and Histomorphometrical Results of a 3-D Printed Biphasic Calcium Phosphate Ceramic 7 Years After Insertion in a Human Maxillary Alveolar Ridge.Frontiers in bioengineering and biotechnology · 2021Article
- Computer simulations on the mechanical behaviors of biphasic calcium phosphates.Journal of molecular modeling · 2017Article
- Stepping into the omics era: Opportunities and challenges for biomaterials science and engineering.Acta biomaterialia · 2016Review
- Histological evaluation of a biomimetic material in bone regeneration after one year from graft.Annali di stomatologia · 2014Article
- Ectopic osteoid and bone formation by three calcium-phosphate ceramics in rats, rabbits and dogs.PloS one · 2014Article
- Calcium Orthophosphate-Based Bioceramics.Materials (Basel, Switzerland) · 2013Review
- The effect of particle size on the osteointegration of injectable silicate-substituted calcium phosphate bone substitute materials.Journal of biomedical materials research. Part B, Applied biomaterials · 2013Article
- Negative pressure therapy stimulates healing of critical-size calvarial defects in rabbits.BoneKEy reports · 2013Article
- Synthetic bone substitute engineered with amniotic epithelial cells enhances bone regeneration after maxillary sinus augmentation.PloS one · 2013Article
- In vitro osteoclast-like and osteoblast cells' response to electrospun calcium phosphate biphasic candidate scaffolds for bone tissue engineering.Journal of materials science. Materials in medicine · 2012Article
- Regenerative medicine: Are calcium phosphate ceramics 'smart' biomaterials?Nature reviews. Rheumatology · 2011Article
- Induction of bone formation by transforming growth factor-beta2 in the non-human primate Papio ursinus and its modulation by skeletal muscle responding stem cells.Cell proliferation · 2010Article
- Biomimetism, biomimetic matrices and the induction of bone formation.Journal of cellular and molecular medicine · 2009Review
- Simple application of fibronectin-mimetic coating enhances osseointegration of titanium implants.Journal of cellular and molecular medicine · 2009Article
- Biomimetic hydroxyapatite used in the treatment of periodontal intrabony pockets: clinical and radiological analysis.Annali di stomatologiaArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term studies in the non-human primate Chacma baboon Papio ursinus were set to investigate the induction of bone formation by biphasic hydroxyapatite/p-tricalcium phosphate (HA/beta-TCP) biomimetic matrices. HA/beta-TCP biomimetic matrices in a pre-sinter ratio (wt%) of 40/60 and 20/80, respectively, were sintered and implanted in the rectus abdominis and in calvarial defects of four adult baboons. The post-sinter phase content ratios were 19/81 and 4/96, respectively. Morphological analyses on day 90 and 365 showed significant induction of bone formation within concavities of the biomimetic matrices with substantial bone formation by induction and resorption/dissolution of the implanted matrices. One year after implantation in calvarial defects, 4/96 biphasic biomimetic constructs showed prominent induction of bone formation with significant dissolution of the implanted scaffolds. The implanted smart biomimetic matrices induce de novo bone formation even in the absence of exogenously applied osteogenic proteins of the transforming growth factor-beta(TGF-beta) superfamily. The induction of bone formation biomimetizes the remodelling cycle of the cortico-cancellous bone of primates whereby resorption lacunae, pits and concavities cut by osteoclastogenesis are regulators of bone formation by induction. The concavities assembled in HA/beta-TCP biomimetic bioceramics are endowed with multifunctional pleiotropic self-assembly capacities initiating and promoting angiogenesis and bone formation by induction. Resident mesenchymal cells differentiate into osteoblastic cell lines expressing, secreting and embedding osteogenic soluble molecular signals of the TGF-beta superfamily within the concavities of the biomimetic matrices initiating bone formation as a secondary response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.