ArticleJournal of cellular and molecular medicine2008
Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders.
Article in Journal of cellular and molecular medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Anticoagulants and cancer mortality in the Finnish randomized study of screening for prostate cancer.Cancer causes & control : CCC · 2019Trial
- The Dynamic Landscape of the Coagulome of Metastatic Malignant Melanoma.International journal of molecular sciences · 2025Article
- Haemophilia and Cancer: A Literature Review.Journal of clinical medicine · 2024Review
- Tissue factor (coagulation factor III): a potential double-edge molecule to be targeted and re-targeted toward cancer.Biomarker research · 2023Review
- Management of Hemophilia in Older Patients.Drugs & aging · 2017Review
- Mutations in CoagulationTH open : companion journal to thrombosis and haemostasis · 2017Article
- High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Targeting clotting proteins in cancer therapy - progress and challenges.Thrombosis research · 2016Review
- Role of the protein C receptor in cancer progression.Thrombosis research · 2014Review
- Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice.Journal of thrombosis and haemostasis : JTH · 2014Article
- Haemophilia and cancer: a personal perspective.Blood transfusion = Trasfusione del sangue · 2013Review
- Irradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivo.PloS one · 2013Article
- Tissue factor and cancer.Thrombosis research · 2012Review
- Pathway-based classification of cancer subtypes.Biology direct · 2012Article
- Fibrin serves as a divalent ligand that regulates neutrophil-mediated melanoma cells adhesion to endothelium under shear conditions.American journal of physiology. Cell physiology · 2012Article
- Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation.Cancer letters · 2011Article
- A low molecular weight heparin inhibits experimental metastasis in mice independently of the endothelial glycocalyx.PloS one · 2010Article
- Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion.Cancer research · 2010Article
- Article
- Are haemophiliacs protected against cancer development? Prospective controlled studies are needed.Journal of cellular and molecular medicine · 2009Article
Corrections and comments
- Commented on by
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental animal studies as well as clinical trials have shown that interventions targeting the blood coagulation cascade inhibit cancer cell metastasis. These data support the hypothesis that congenital prothrombotic disorders, like factor V Leiden, facilitate metastasis whereas bleeding disorders, like haemophilia impede metastasis. To test this hypothesis, we subjected factor V Leiden and factor VIII deficient mice to a murine model of experimental lung metastasis. In this model, B16F10 murine melanoma cells are injected into the tail vein resulting in multiple lung metastases within 20 days. Both hemi- and homozygous factor VIII deficient mice were protected against lung metastasis compared to wild-type littermate controls. In contrast, homozygous factor V Leiden mice developed more metastases than wild-type littermates, whereas heterozygous carriers showed an intermediate number of pulmonary foci. Overall, these data show that a congenital susceptibility to either bleeding or thrombosis modifies the metastatic capacity of cancer cells in the bloodstream and suggest that procoagulant phenotypes are a risk factor for tumour metastasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.