Trial reportThe Journal of clinical psychiatry2008
Pharmacologic treatment of postpartum women with new-onset major depressive disorder: a randomized controlled trial with paroxetine.
Trial report in The Journal of clinical psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 7 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Effect of Parenting Interventions on Perinatal Depression and Implications for Infant Developmental Outcomes: A Systematic Review and Meta-Analysis.Clinical child and family psychology review · 2022Pooled it
- Comparative efficacy and acceptability of pharmacotherapies for postpartum depression: A systematic review and network meta-analysis.Frontiers in pharmacology · 2022Pooled it
- Antidepressant treatment for postnatal depression.The Cochrane database of systematic reviews · 2021Pooled it
- Treatment of depression, anxiety, and trauma-related disorders during the perinatal period: A systematic review.Clinical psychology review · 2018Pooled it
- Antidepressants for preventing postnatal depression.The Cochrane database of systematic reviews · 2018Pooled it
- Antidepressant treatment for postnatal depression.The Cochrane database of systematic reviews · 2014Pooled it
- A meta-analysis of treatments for perinatal depression.Clinical psychology review · 2011Pooled it
- Transdermal estradiol for postpartum depression: results from a pilot randomized, double-blind, placebo-controlled study.Archives of women's mental health · 2020Trial
- Perinatal Dyadic Psychotherapy for postpartum depression: a randomized controlled pilot trial.Archives of women's mental health · 2015Trial
- A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression.Psychopharmacology · 2014Trial
- Comparative Efficacy of Interventions for the Prevention and Treatment of Postpartum Depression: A Bayesian Network Meta-analysis.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Review
- First Reported Case of Dissociative Symptoms Associated With Zuranolone Use in Peripartum Depression.Cureus · 2026Article
- Supplementary approaches to perinatal depression: a review of pathogenesis, herbal interventions, and dietary supplements.Frontiers in psychology · 2025Review
- Fecal microbiota as a predictor of acupuncture responses in patients with postpartum depressive disorder.Frontiers in cellular and infection microbiology · 2023Article
- Development of neuroactive steroids for the treatment of postpartum depression.Journal of neuroendocrinology · 2022Review
- Advances in pharmacotherapy for postpartum depression: a structured review of standard-of-care antidepressants and novel neuroactive steroid antidepressants.Therapeutic advances in psychopharmacology · 2022Review
- Treating Postpartum Depression: What Do We Know about Brexanolone?Diseases (Basel, Switzerland) · 2021Review
- Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Meta-Analysis of Pharmacotherapy.Psychiatric research and clinical practice · 2021Review
- Is Postpartum Depression Different From Depression Occurring Outside of the Perinatal Period? A Review of the Evidence.Focus (American Psychiatric Publishing) · 2020Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveApproximately 6% to 8% of postpartum women suffer from major depressive disorder (MDD), but only a few controlled trials have investigated the efficacy of pharmacologic treatments. The current study determined the relative efficacy of paroxetine compared to placebo in the treatment of acute postpartum MDD.
methodThis was an 8-week, multicenter, parallel, placebo-controlled trial of paroxetine for treatment of postpartum depression. Subjects were eligible if they had an onset of DSM-IV MDD after, but within 3 months of, delivery and had a minimum score of 16 on the 17-item Hamilton Rating Scale for Depression (HAM-D-17) at intake. Seventy women were randomly assigned to either immediate-release paroxetine or matching placebo, and 31 completed the trial. Subjects were reassessed with the HAM-D-17, the Inventory of Depressive Symptomatology-Self-Report (IDS-SR) form and the Clinical Global Impressions (CGI) scales. The study was conducted between 1997 and 2004.
resultsBoth groups improved over time and did not differ significantly on the HAM-D-17 or IDS-SR at follow-up. However, greater improvement in overall mean +/- SD clinical severity was found for the paroxetine (Clinical Global Impressions-Severity of Illness [CGI-S] score = 1.8 +/- 1.4) compared with the control group (CGI-S score = 3.1 +/- 1.4; p = .05). The paroxetine group also had a significantly higher rate of remission, compared to the placebo group (37% vs. 15%, odds ratio = 3.5, 95% CI = 1.1 to 11.5). The rate of adverse effects did not differ significantly between groups.
conclusionStudy results were limited by lower than expected enrollment and higher than anticipated attrition. Nonetheless, paroxetine treatment was associated with a significantly higher rate of remission among women with postpartum onset of MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.